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心脏转移:一例黑色素瘤临床病例

Heart Dissemination: A Clinical Case of Melanoma.

作者信息

André Diogo, André Teresa, Gouveia Fabiana, Nascimento Rafael, Chaves António, Braza O Maria

机构信息

Internal Medicine, Hospital Central do Funchal, Funchal, Portugal.

Oncology, Hospital Central do Funchal, Funchal, Portugal.

出版信息

Case Rep Med. 2021 Jun 30;2021:8562402. doi: 10.1155/2021/8562402. eCollection 2021.

Abstract

. Primitive malignant heart tumours are rare, specific cases. The presence of cardiac metastases, often in the pericardium, besides indicating disseminated oncological disease, represents a diagnostic challenge since they tend to be asymptomatic. Malignant cutaneous melanoma (MCM) is the neoplasm that most often affects the heart. . The authors describe a case report of a 59-year-old female patient with a history of non-insulin-treated diabetes mellitus, arterial hypertension, dyslipidemia, and remitting cutaneous malignant melanoma who underwent skin excision, lymphadenectomy, and adjuvant chemotherapy in 1996. In April 2014, she resorted to emergency service due to epigastric pain and progressive tiredness. Due to the persistence of the complaints, abdominal ultrasound was performed, which showed a large pericardial effusion, corroborated later by teleradiography and echocardiography. The patient underwent pericardiocentesis, which isolated neoplastic cells. A computed tomography study of the chest, abdomen, and pelvis revealed bilateral and pericardial pleural effusion, as well as alterations suggestive of pericardial and pulmonary metastasis. Later, fine-needle aspiration puncture of the left posterior cervical nodule confirmed histologically malignant melanoma metastasis. . Given the natural history of melanoma that when metastasized has an overall survival of 15-20% for 5 years, its metastatic spread may occur several years after its surgical excision. Thus, patients with a history of melanoma and heart failure who develop new cardiac symptoms of unknown aetiology should undergo imaging studies such as echocardiography, computed tomography, and magnetic resonance imaging.

摘要

原发性恶性心脏肿瘤是罕见的特殊病例。心脏转移瘤的存在,通常位于心包,除了提示肿瘤已播散外,也是一个诊断难题,因为它们往往没有症状。恶性皮肤黑色素瘤(MCM)是最常累及心脏的肿瘤。作者描述了一例59岁女性患者的病例报告,该患者有非胰岛素治疗的糖尿病、动脉高血压、血脂异常病史,曾患缓解期皮肤恶性黑色素瘤,并于1996年接受了皮肤切除、淋巴结清扫和辅助化疗。2014年4月,她因上腹部疼痛和进行性疲劳前往急诊。由于症状持续,进行了腹部超声检查,显示大量心包积液,随后经远程放射学和超声心动图证实。患者接受了心包穿刺术,分离出肿瘤细胞。胸部、腹部和骨盆的计算机断层扫描研究显示双侧和心包胸膜积液,以及提示心包和肺转移的改变。后来,左后颈部结节的细针穿刺活检在组织学上证实为恶性黑色素瘤转移。鉴于黑色素瘤的自然病程,发生转移后5年的总生存率为15%-20%,其转移可能在手术切除后数年发生。因此,有黑色素瘤病史且出现病因不明的新心脏症状的心力衰竭患者应接受超声心动图、计算机断层扫描和磁共振成像等影像学检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5be1/8263222/a2035daae3fa/CRIM2021-8562402.001.jpg

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