University of Medicine and Pharmacy, Cluj Napoca, Romania.
University of Oradea, Romania.
J Pak Med Assoc. 2020 May;70(5):840-844. doi: 10.5455/JPMA.12075.
To examine the relationship of carotid intima-media thickness with weight-gain, overweight and obesity..
The experimental, analytical study was conducted at the CF University Hospital, Cluj-Napoca, Romania, from 2012 to 2014, and comprised randomly selected in patients from the Medical Ward. The patients were divided into normal-weight subjects in Group I and overweight and obese subjects in Group II Intimate-media thickness was measured by carotid Doppler ultrasound. Data was analysed using SPSS 13.
Of the 111 subjects, Group I had 27(%) and Group II had 84(%) subjects. Mean carotid intimamedia thickness was significantly greater (p<0.001) in Group II compared to Group I, especially in those with metabolic syndrome (p<0.001) and higher high-sensitivity C reactive protein (p<0.05). With the exception of Group II where there was a direct correlation (p<0.05) between triglycerides and intimamedia thickness, and an inverse correlation (p<0.05) between high-density lipoprotein and intimamedia thickness, no significant correlations were recorded (p>0.05).
Intima-media thickness was found to be increased in asymptomatic overweight and obese subjects, significantly higher in those with associated metabolic syndrome and high levels of highsensitivity C-reactive protein, as an indication of the presence of early, subclinical atherosclerosis.
探讨颈动脉内膜中层厚度与体重增加、超重和肥胖的关系。
本实验性、分析性研究于 2012 年至 2014 年在罗马尼亚克卢日-纳波卡的 CF 大学医院进行，研究对象为来自内科病房的随机选择的患者。患者被分为正常体重组（I 组）和超重肥胖组（II 组）。采用颈动脉多普勒超声测量内膜中层厚度。采用 SPSS 13 对数据进行分析。
在 111 名患者中，I 组有 27（%）例，II 组有 84（%）例。与 I 组相比，II 组的颈动脉内膜中层厚度明显更大（p<0.001），尤其是在代谢综合征患者中（p<0.001）和高敏 C 反应蛋白水平较高的患者中（p<0.05）。除了 II 组的甘油三酯与内膜中层厚度呈直接相关（p<0.05），高密度脂蛋白与内膜中层厚度呈负相关（p<0.05）外，其他组之间未记录到显著相关性（p>0.05）。
在无症状超重和肥胖患者中发现内膜中层厚度增加，在伴有代谢综合征和高敏 C 反应蛋白水平升高的患者中显著更高，表明存在早期亚临床动脉粥样硬化。
