训练和西红花苷补充对 2 型糖尿病大鼠肝组织线粒体生物发生和氧化还原敏感转录因子的影响。
Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats.
机构信息
Department of Sport Physiology, Yasouj Branch, Islamic Azad University, Yasouj, Iran.
Department of Nursing, Medical University of Yasouj, Yasouj, Iran.
出版信息
Arch Physiol Biochem. 2022 Oct;128(5):1215-1220. doi: 10.1080/13813455.2020.1762663. Epub 2020 May 13.
Present study investigated the effect of continued training (CT) and interval training (IT) with crocin (C) supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetes (T2D) rats. Forty-eight high fat diet and streptozotocin- induced diabetic rats (mean age: 20 weeks, mean weight: 360.12 ± 12.11 g) were randomly divided into six groups including: (1) sham (Sh), (2) CT, (3) IT, (4) C (25 mg/kg/day), (5) CT + C, and (6) IT + C. IT and CT were performed 8 weeks for five sessions per week on treadmill with 80-85% and 50-55% of maximum speed running respectively. IT, CT and C decreased AP1 and increased LCAD ( ≤ .05); C increased SIRT1 ( ≤ .05); IT + C and CT + C decreased AP1 as well as increased NF-κB and LCAD ( ≤ .05); IT + C increased SIRT1, SIRST3 and PGC1-α ( ≤ .05). It appears that IT along with C compared to CT and C have favourable effect on mitochondrial biogenesis factors.
本研究探讨了连续训练（CT）和间歇训练（IT）联合藏红花素（C）补充对 2 型糖尿病（T2D）大鼠肝组织线粒体生物发生和氧化还原敏感转录因子的影响。48 只高脂肪饮食和链脲佐菌素诱导的糖尿病大鼠（平均年龄：20 周，平均体重：360.12±12.11g）随机分为六组：（1）假手术（Sh），（2）CT，（3）IT，（4）C（25mg/kg/天），（5）CT+C，和（6）IT+C。IT 和 CT 分别在跑步机上进行 8 周，每周 5 次，跑步速度分别为最大速度的 80-85%和 50-55%。IT、CT 和 C 降低了 AP1 并增加了 LCAD（≤.05）；C 增加了 SIRT1（≤.05）；IT+C 和 CT+C 降低了 AP1，增加了 NF-κB 和 LCAD（≤.05）；IT+C 增加了 SIRT1、SIRST3 和 PGC1-α（≤.05）。与 CT 和 C 相比，IT 联合 C 似乎对线粒体生物发生因子有更有利的影响。
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