Department of Sport Physiology, Yasouj Branch, Islamic Azad University, Yasouj, Iran.
Department of Nursing, Medical University of Yasouj, Yasouj, Iran.
Arch Physiol Biochem. 2022 Oct;128(5):1215-1220. doi: 10.1080/13813455.2020.1762663. Epub 2020 May 13.
Present study investigated the effect of continued training (CT) and interval training (IT) with crocin (C) supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetes (T2D) rats. Forty-eight high fat diet and streptozotocin- induced diabetic rats (mean age: 20 weeks, mean weight: 360.12 ± 12.11 g) were randomly divided into six groups including: (1) sham (Sh), (2) CT, (3) IT, (4) C (25 mg/kg/day), (5) CT + C, and (6) IT + C. IT and CT were performed 8 weeks for five sessions per week on treadmill with 80-85% and 50-55% of maximum speed running respectively. IT, CT and C decreased AP1 and increased LCAD ( ≤ .05); C increased SIRT1 ( ≤ .05); IT + C and CT + C decreased AP1 as well as increased NF-κB and LCAD ( ≤ .05); IT + C increased SIRT1, SIRST3 and PGC1-α ( ≤ .05). It appears that IT along with C compared to CT and C have favourable effect on mitochondrial biogenesis factors.
本研究探讨了连续训练（CT）和间歇训练（IT）联合藏红花素（C）补充对 2 型糖尿病（T2D）大鼠肝组织线粒体生物发生和氧化还原敏感转录因子的影响。48 只高脂肪饮食和链脲佐菌素诱导的糖尿病大鼠（平均年龄：20 周，平均体重：360.12±12.11g）随机分为六组：（1）假手术（Sh），（2）CT，（3）IT，（4）C（25mg/kg/天），（5）CT+C，和（6）IT+C。IT 和 CT 分别在跑步机上进行 8 周，每周 5 次，跑步速度分别为最大速度的 80-85%和 50-55%。IT、CT 和 C 降低了 AP1 并增加了 LCAD（≤.05）；C 增加了 SIRT1（≤.05）；IT+C 和 CT+C 降低了 AP1，增加了 NF-κB 和 LCAD（≤.05）；IT+C 增加了 SIRT1、SIRST3 和 PGC1-α（≤.05）。与 CT 和 C 相比，IT 联合 C 似乎对线粒体生物发生因子有更有利的影响。
