Dai Y-X, Yeh F-Y, Chou Y-J, Chang Y-T, Chen T-J, Li C-P, Wu C-Y
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Eur Acad Dermatol Venereol. 2020 Nov;34(11):2593-2599. doi: 10.1111/jdv.16595. Epub 2020 Jun 22.
Most evidence regarding the relationship between cigarette smoking and risk of rosacea is obtained from cross-sectional or case-control studies.
To examine the association between smoking and risk of developing rosacea.
Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Incident cases of rosacea were identified from the National Health Insurance database. Cox proportional hazard model was used for the analyses.
Of the 59 973 participants, 379 developed rosacea during a mean follow-up of 10.8 years. After adjustment for potential confounders, current smokers had a lower risk of rosacea than never smokers [adjusted hazard ratio (aHR) 0.60; 95% confidence interval (CI) 0.39-0.92]. An increase in smoking intensity was associated with a decreased risk of rosacea among current smokers (P = 0.0101). Compared with never smokers, current smokers of >15 cigarettes/day had an aHR of 0.51 (95% CI: 0.26-0.99) for rosacea. For incident rosacea, the aHRs (95% CIs) of current smokers of ≤10 years of smoking and ≤10 pack-years of smoking were 0.44 (0.22-0.88) and 0.51 (0.29-0.89), respectively. Former smoking was not associated with rosacea risk.
Current smoking was significantly associated with a decreased risk of rosacea.
关于吸烟与酒渣鼻风险之间关系的大多数证据来自横断面研究或病例对照研究。
研究吸烟与患酒渣鼻风险之间的关联。
参与者来自台湾国民健康访谈调查的四轮调查（2001年、2005年、2009年和2013年）。酒渣鼻的新发病例从国民健康保险数据库中识别。采用Cox比例风险模型进行分析。
在59973名参与者中，379人在平均10.8年的随访期间患上酒渣鼻。在对潜在混杂因素进行调整后，当前吸烟者患酒渣鼻的风险低于从不吸烟者[调整后风险比（aHR）为0.60；95%置信区间（CI）为0.39 - 0.92]。吸烟强度增加与当前吸烟者患酒渣鼻风险降低相关（P = 0.0101）。与从不吸烟者相比，每天吸烟超过15支的当前吸烟者患酒渣鼻的aHR为0.51（95%CI：0.26 - 0.99）。对于酒渣鼻新发病例，吸烟≤10年且吸烟量≤10包年的当前吸烟者的aHR（95%CI）分别为0.44（0.22 - 0.88）和0.51（0.29 - 0.89）。既往吸烟与酒渣鼻风险无关。
当前吸烟与酒渣鼻风险降低显著相关。
