Penetar D M, Haegerstrom-Portnoy G, Jones R T
Letterman Army Institute of Research, Smith-Kettlewell Eye Research Foundation, San Francisco, CA.
Aviat Space Environ Med. 1988 Dec;59(12):1125-32.
Combinations of atropine (up to 4 mg.70 kg-1) and 2-PAM Cl (up to 1200 mg.70 kg-1) were studied for their effects on a pursuit tracking task, six visual functions, heart rate and blood pressure, and cognitive functions as measured by six psychological tests. Tracking performance in both bright light and dim light was significantly degraded up to 3.5 h after injection. High- and low-contrast near acuity was significantly altered up to 6 h after injection, whereas accommodation and pupil size remained altered for 24 h. Elevated pulse rates were observed for 4 h. Elevated systolic blood pressures were observed for 2 h while diastolic pressures remained elevated for 6 h. No drug effects were found for the psychological tests. Overall, the observed effects of these two drugs in combination are qualitatively similar to those of atropine alone although they are of greater magnitude. On two measures (accommodation and diastolic blood pressure), 2-PAM Cl was found to significantly potentiate the atropine effect.
研究了阿托品（高达4毫克·70千克-1）和氯解磷定（高达1200毫克·70千克-1）的组合对追踪任务、六种视觉功能、心率和血压以及通过六项心理测试测量的认知功能的影响。注射后长达3.5小时，强光和弱光下的追踪表现均显著下降。注射后长达6小时，高对比度和低对比度近视力显著改变，而调节和瞳孔大小在24小时内仍有变化。观察到脉搏率升高4小时。收缩压升高2小时，舒张压升高6小时。心理测试未发现药物效应。总体而言，这两种药物联合使用的观察效果在质量上与单独使用阿托品相似，尽管程度更大。在两项指标（调节和舒张压）上，发现氯解磷定显著增强了阿托品的作用。
