Qiu Pei, Cai Run-Lin, Li Lin, She Zhi-Gang
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China.
Chin J Nat Med. 2020 Apr;18(4):256-260. doi: 10.1016/S1875-5364(20)30031-5.
Three new isocoumarin derivatives, (S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one (1), (S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one (2) and (R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl) propyl acetate (3), along with four known compounds (4-7) were isolated from a mangrove endophytic fungus Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of 1-3 were further determined by X-ray diffraction analysis and optical rotations. Compounds 3, 6 and 7 showed promising inhibitory activity against α-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin (IC 141.2 μmol·L).
从一种红树林内生真菌青霉属菌株YYSJ-3中分离得到了三种新的异香豆素衍生物，即(S)-6,8-二羟基-5-(甲氧基甲基)-3,7-二甲基异色满-1-酮(1)、(S)-6,8-二羟基-3,5,7-三甲基异色满-1-酮(2)和(R)-2-氯-3-(8-羟基-6-甲氧基-1-氧代-1H-异色烯-3-基)丙基乙酸酯(3)，以及四种已知化合物(4-7)。它们的结构是基于广泛的光谱数据和高分辨电喷雾电离质谱分析确定的。1-3的绝对构型通过X射线衍射分析和旋光进一步确定。化合物3、6和7对α-葡萄糖苷酶显示出有前景的抑制活性，其活性强于阳性对照1-脱氧野尻霉素(IC 141.2 μmol·L)。
