State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Beijing Key Laboratory of Bioactive Substance and Functional Foods, Beijing Union University, Beijing 100191, China.
Mar Drugs. 2021 Jun 24;19(7):362. doi: 10.3390/md19070362.
Two new diterpenoids, hypoxyterpoids A () and B (), and four new isocoumarin derivatives, hypoxymarins A-D (-), together, with seven known metabolites ( and -) were obtained from the crude extract of the mangrove-derived fungus sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds , , , and were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4' in and C-9 in were determined by [Rh(OCOCF)]-induced ECD spectra. Compound showed moderate -glucosidase inhibitory activities with IC values of 741.5 ± 2.83 μM. Compounds and exhibited DPPH scavenging activities with IC values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.
从红树林来源的真菌 Hypoxylon sp. 的粗提物中分离得到了两个新的二萜类化合物，hypoxyterpoids A()和 B()，以及四个新的异香豆素衍生物，hypoxymarins A-D(-)，此外，还得到了七个已知代谢物(和-)。根据 1D/2D 核磁共振(NMR)谱和质谱分析，确定了新化合物的结构。通过比较实验和计算的电子圆二色性(ECD)光谱，确定了化合物、、、和的绝对构型，通过[Rh(OCOCF)]-诱导的 ECD 光谱确定了化合物和中的 C-4'和 C-9 的绝对构型。化合物显示出中等的 -葡萄糖苷酶抑制活性，IC 值为 741.5±2.83μM。化合物和对 DPPH 自由基具有清除活性，IC 值分别为 15.36±0.24μM 和 3.69±0.07μM。
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