Department of Psychology & Logopedics, University of Helsinki, Helsinki, Finland.
Department of Psychology & Logopedics, University of Helsinki, Helsinki, Finland; National Institute of Health and Welfare, Helsinki, Finland; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Semin Fetal Neonatal Med. 2020 Jun;25(3):101113. doi: 10.1016/j.siny.2020.101113. Epub 2020 Apr 28.
Preterm birth research is poised to explore the mental health of adults born very preterm(VP; <32 weeks gestational age) and/or very low birth weight(VLBW; <1500g) through individual participant data meta-analyses, but first the previous evidence needs to be understood. We systematically reviewed and assessed the quality of the evidence from VP/VLBW studies with mental health symptoms or disorders appearing in adulthood, excluding childhood onset disorders. Participants (≥18 years, born >1970) included VP/VLBW individuals with controls born at term(≥37 weeks) or with normal birth weight(NBW; ≥2500g). Thirteen studies were included. Studies consistently showed an increased risk for psychotropic medication use for VP/VLBW adults in comparison to NBW/term controls, but whether VP/VLBW adults have an increased risk for mental health disorders or symptoms appearing in adulthood remains uncertain. The quality of the evidence was moderate (65.8%) to high (34.2%). Further research in larger samples is needed.
早产儿出生研究即将通过个体参与者数据荟萃分析来探索非常早产儿（VP；<32 孕周）和/或极低出生体重儿（VLBW；<1500g）的成年人的心理健康状况，但首先需要了解之前的证据。我们系统地回顾和评估了成年后出现心理健康症状或障碍的 VP/VLBW 研究的证据质量，排除了儿童期发病的疾病。参与者（≥18 岁，出生时间>1970 年）包括 VP/VLBW 个体以及足月（≥37 周）出生或出生体重正常（≥2500g）的对照组。共纳入 13 项研究。研究一致表明，与 NBW/足月对照组相比，VP/VLBW 成年人使用精神药物的风险增加，但 VP/VLBW 成年人是否存在成年后出现心理健康障碍或症状的风险增加仍不确定。证据质量为中等到高（分别为 65.8%和 34.2%）。需要在更大的样本中进行进一步的研究。
