大鼠肾皮质和髓质线粒体对缺血损伤的敏感性差异。
Different susceptibility of cortical and medullary rat kidney mitochondria to ischemic injury.
作者信息
Jung K, Pergande M
机构信息
Department of Experimental Organ Transplantation, University Hospital Charité, Humboldt University Berlin.
出版信息
Biomed Biochim Acta. 1988;47(6):455-60.
Rat kidneys were exposed for different times to in vitro ischemia at 37 degrees C. Then the mitochondria of cortex and medulla were isolated and their respiratory qualities were determined. In dependence on the ischemic time, the active respiration (state 3) and the respiratory control index decreased whereas the resting state respiration (state 4) increased. The cortical mitochondria were affected more strongly by ischemia than medullary mitochondria. Therefore, the different susceptibility of cortical and medullary mitochondria to ischemia does not explain the suggested high risk of medulla for ischemia.
将大鼠肾脏在37℃下进行不同时间的体外缺血处理。然后分离出皮质和髓质的线粒体并测定其呼吸特性。根据缺血时间的不同，活性呼吸（状态3）和呼吸控制指数下降，而静息状态呼吸（状态4）增加。皮质线粒体比髓质线粒体受缺血的影响更强。因此，皮质和髓质线粒体对缺血的不同易感性并不能解释所提出的髓质缺血高风险。
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