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具有 2-(哌嗪-1-基)-(噻吩-2-基亚甲基)乙胺部分的三种希夫碱的合成及光谱鉴定：作为新型胰脂肪酶抑制剂的热、DFT、抗氧化、抗菌和分子对接研究。

Synthesis and Spectral Identification of Three Schiff Bases with a 2-(Piperazin-1-yl)--(thiophen-2-yl methylene)ethanamine Moiety Acting as Novel Pancreatic Lipase Inhibitors: Thermal, DFT, Antioxidant, Antibacterial, and Molecular Docking Investigations.

机构信息

Department of Chemistry and Earth Sciences, Qatar University, P.O. Box 2713, Doha, Qatar.

Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine.

出版信息

Molecules. 2020 May 11;25(9):2253. doi: 10.3390/molecules25092253.

DOI:10.3390/molecules25092253
PMID:32403218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7248877/
Abstract

Three new tetradentate NNNS Schiff bases (-) derived from 2-(piperidin-4-yl)ethanamine were prepared in high yields. UV-Visible and FTIR spectroscopy were used to monitor the dehydration reaction between 2-(piperidin-4-yl)ethanamine and the corresponding aldehydes. Structures of the derived Schiff bases were deduced by H and C NMR, FTIR, UV-Vis, MS, EA, EDS, and TG-derived physical measurements. DFT/B3LYP theoretical calculations for optimization, TD-DFT, frequency, Molecular Electrostatic Potential (MEP), and highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) / were performed for . The in vitro antimicrobial activities of the three Schiff bases were evaluated against several types of bacteria by disk diffusion test using Gentamicin as the standard antibiotic. Schiff bases revealed good antioxidant activity by the DPPH method, and the IC values were compared to the Trolox standard. Pancreatic porcine lipase inhibition assay of the synthesized compounds revealed promising activity as compared to the Orlistat reference.

摘要

三种新的四齿 NNNSSchiff 碱（-）是由 2-（哌啶-4-基）乙胺高收率制备的。使用 UV-Visible 和 FTIR 光谱监测 2-（哌啶-4-基）乙胺与相应的醛之间的脱水反应。衍生的 Schiff 碱的结构通过 H 和 C NMR、FTIR、UV-Vis、MS、EA、EDS 和 TG 衍生的物理测量来推断。进行了 DFT/B3LYP 理论计算以进行优化、TD-DFT、频率、分子静电势（MEP）和最高占据分子轨道（HOMO）和最低未占据分子轨道（LUMO）/。通过使用庆大霉素作为标准抗生素的圆盘扩散试验评估了三种 Schiff 碱对几种类型细菌的体外抗菌活性。Schiff 碱通过 DPPH 法显示出良好的抗氧化活性，并且将 IC 值与 Trolox 标准进行了比较。与奥利司他参考药物相比，合成化合物对胰腺猪胰脂肪酶抑制试验显示出有希望的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/3ba6917548a3/molecules-25-02253-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/d7a3cd5705ef/molecules-25-02253-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/3ba6917548a3/molecules-25-02253-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/5d83724fc557/molecules-25-02253-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/5b234ded3902/molecules-25-02253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/f47ff6be41ca/molecules-25-02253-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/13a74014b3d2/molecules-25-02253-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/dc4aa5414d47/molecules-25-02253-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/9baa6e10f1ad/molecules-25-02253-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/4442f0683843/molecules-25-02253-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/18dda7de203d/molecules-25-02253-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/965702038134/molecules-25-02253-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/d7a3cd5705ef/molecules-25-02253-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d1a/7248877/3ba6917548a3/molecules-25-02253-g010.jpg

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2
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3
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