Nasello A G, Felicio L F
Departamento de Ciências Fisiológicas, Faculdade de Ciências Médicas da Santa Casa, São Paulo, Brasil.
Braz J Med Biol Res. 1988;21(4):841-3.
Bromopride (BRO), a dopamine D2 blocker used in gastroenterology clinics, was tested acutely in rats for effects on general activity, measured in an open-field test, and on inhibitory avoidance behavior. Rats that received 2.5 and 5.0 mg/kg BRO showed lower locomotion and rearing frequencies than controls, and 5.0 mg/kg BRO blocked the inhibitory avoidance response. The data suggest that BRO may have neuroleptic effects.
溴必利（BRO）是一种用于胃肠病诊所的多巴胺D2受体阻滞剂，在大鼠中进行了急性试验，以研究其对旷场试验中测量的一般活动以及对抑制性回避行为的影响。接受2.5和5.0mg/kg溴必利的大鼠的运动和站立频率低于对照组，5.0mg/kg溴必利阻断了抑制性回避反应。数据表明溴必利可能具有抗精神病作用。
