Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China.
Ningbo Diagnostic Pathology Center, Zhejiang Province, Ningbo, China.
Int J Surg Pathol. 2020 Oct;28(7):728-734. doi: 10.1177/1066896920918289. Epub 2020 May 13.
Papillary renal neoplasm with reverse polarity is a form of recently described tumor. These tumors are defined by GATA3 positivity, negative vimentin staining, and the presence of both papillary structures and a layer of eosinophilic cells with apical nuclei and a granular cytoplasm. In the present report, we review 7 cases of papillary renal neoplasm with reverse polarity that were GATA3+ and vimentin-, consistent with past reports. In all 7 of these cases, we found that these tumors were additionally positive for 34βE12. All 7 of these tumors were categorized as stage pT1. On histological examination, these tumors exhibited branching papillae with apical nuclei. All 7 of these patients were alive on most recent follow-up, with 6 being disease free and one having developed prostate cancer. Together, this overview of 7 additional cases of papillary renal neoplasm with reverse polarity offers further insight into this rare and poorly understood disease.
具有反向极性的乳头状肾肿瘤是最近描述的一种肿瘤形式。这些肿瘤的定义是 GATA3 阳性、波形蛋白阴性，并且具有乳头状结构和一层嗜酸性细胞，这些细胞具有顶端核和颗粒状细胞质。在本报告中，我们回顾了 7 例 GATA3+和波形蛋白-的具有反向极性的乳头状肾肿瘤，与以往的报道一致。在所有这 7 例病例中，我们发现这些肿瘤还对 34βE12 呈阳性。所有这 7 例肿瘤均被归类为 pT1 期。在组织学检查中，这些肿瘤表现为具有顶端核的分支状乳头。在最近的随访中，这 7 例患者均存活，其中 6 例无疾病，1 例患有前列腺癌。综上所述，这 7 例具有反向极性的乳头状肾肿瘤的额外病例进一步深入了解了这种罕见且了解甚少的疾病。
