Siri Susanna R A, Eliassen Bent M, Broderstad Ann R, Melhus Marita, Michalsen Vilde L, Jacobsen Bjarne K, Burchill Luke J, Braaten Tonje
Department of Community Medicine, Centre for Sami Health Research, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway
Faculty of Nursing and Health Sciences, Nord University, Bodo, Nordland, Norway.
Open Heart. 2020 May;7(1). doi: 10.1136/openhrt-2019-001213.
Previous studies have suggested that Sami have a similar risk of myocardial infarction and a higher risk of stroke compared with non-Sami living in the same geographical area.
Participants in the SAMINOR 1 Survey (2003-2004) aged 30 and 36-79 years were followed to the 31 December 2016 for observation of fatal or non-fatal events of acute myocardial infarction (AMI), coronary heart disease (CHD), ischaemic stroke (IS), stroke and a composite endpoint (fatal or non-fatal AMI or stroke).
Compare the risk of AMI, CHD, IS, stroke and the composite endpoint in Sami and non-Sami populations, and identify intermediate factors if ethnic differences in risks are observed.
Cox regression models.
The sex-adjusted and age-adjusted risks of AMI (HR for Sami versus non-Sami 0.99, 95% CI: 0.83 to 1.17), CHD (HR 1.03, 95% CI: 0.93 to 1.15) and of the composite endpoint (HR 1.09, 95% CI: 0.95 to 1.24) were similar in Sami and non-Sami populations. Sami ethnicity was, however, associated with increased risk of IS (HR 1.36, 95% CI: 1.10 to 1.68) and stroke (HR 1.31, 95% CI: 1.08 to 1.58). Height explained more of the excess risk observed in Sami than conventional risk factors.
The risk of IS and stroke were higher in Sami and height was identified as an important intermediate factor as it explained a considerable proportion of the ethnic differences in IS and stroke. The risk of AMI, CHD and the composite endpoint was similar in Sami and non-Sami populations.
先前的研究表明，与生活在同一地理区域的非萨米人相比，萨米人患心肌梗死的风险相似，但患中风的风险更高。
对参加2003 - 2004年萨米诺尔1调查、年龄在30岁以及36 - 79岁的参与者进行随访，直至2016年12月31日，以观察急性心肌梗死（AMI）、冠心病（CHD）、缺血性中风（IS）、中风以及复合终点（致命或非致命性AMI或中风）的致命或非致命事件。
比较萨米人和非萨米人群中AMI、CHD、IS、中风以及复合终点的风险，并在观察到风险存在种族差异时确定中间因素。
Cox回归模型。
在萨米人和非萨米人群中，经性别和年龄调整后的AMI风险（萨米人与非萨米人的风险比[HR]为0.99，95%置信区间[CI]：0.83至1.17）、CHD风险（HR 1.03，95% CI：0.93至1.15）以及复合终点风险（HR 1.09，95% CI：0.95至1.24）相似。然而，萨米族与IS风险增加（HR 1.36，95% CI：1.10至1.68）和中风风险增加（HR 1.31，95% CI：1.08至1.58）相关。与传统风险因素相比，身高对萨米人观察到的额外风险的解释作用更大。
萨米人中IS和中风的风险更高，身高被确定为一个重要的中间因素，因为它解释了IS和中风中相当一部分的种族差异。萨米人和非萨米人群中AMI、CHD和复合终点的风险相似。
