Chiappelli Francesco
UCLA Center for the Health Sciences, Los Angeles, CA, USA, Francesco.
Bioinformation. 2020 Feb 12;16(2):139-144. doi: 10.6026/97320630016139. eCollection 2020.
The first report of the unusual manifestation of pneumonia-like symptoms in Wuhan City, China was made on 31 December 2019. Within one week, the Chinese authorities reported that they had identified the causative agent as a new member of the Coronavirus family, the same family of that was responsible for MERS and SARS not so many years ago. The new virus was called Novel Coronavirus 2019 (2019-nCoV). Three weeks later, the World Health Organization declared that 2019-nCoV was capable of direct human-to-human transmission, the virus had spread across several countries in three continents, and had infected close to two thousand people, of whom at least 1 in 5 quite severely. The number of fatalities was fast rising. Yet, the World Health Organization officially announced that there is still at present no recommended anti-nCoV vaccine for subject at-risk, nor treatment for patients with suspected or confirmed nCoV, let alone 2019-nCov. It is therefore timely and critical to propose new possible and practical approaches for preventive interventions for subjects at-risk, and for treatment of patients afflicted with 2019-nCov-induced disease (Corona Virus Disease 2019; COVID-19) before the present situation explodes into a worldwide pandemic. One such potential clinical protocol is proposed as a hypothesis.
2019年12月31日,中国武汉市首次报告出现类似肺炎症状的异常表现。在一周内,中国当局报告称已确定病原体为冠状病毒家族的一个新成员,该家族在几年前还曾引发中东呼吸综合征(MERS)和严重急性呼吸综合征(SARS)。这种新病毒被命名为“2019新型冠状病毒”(2019-nCoV)。三周后,世界卫生组织宣布2019-nCoV能够在人与人之间直接传播,该病毒已蔓延至三大洲的多个国家,感染了近两千人,其中至少五分之一的患者病情相当严重。死亡人数迅速上升。然而,世界卫生组织官方宣布,目前仍没有针对高危人群推荐的抗nCoV疫苗,也没有针对疑似或确诊nCoV患者的治疗方法,更不用说针对2019-nCoV了。因此,在当前形势演变成全球大流行之前,为高危人群提出新的可能且实用的预防干预措施,以及为感染2019-nCoV所致疾病(新型冠状病毒肺炎;COVID-19)的患者提出治疗方法,是及时且至关重要的。本文提出了一种这样的潜在临床方案作为假设。