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瑞典青年员工的童年逆境与常见精神障碍:这种关联是否受成年早期职业阶层的影响?

Childhood adversity and common mental disorders in young employees in Sweden: is the association affected by early adulthood occupational class?

机构信息

Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

Department of Community Health Sciences, Fielding School of Public Health and California Center for Population Research, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2021 Feb;56(2):237-246. doi: 10.1007/s00127-020-01874-0. Epub 2020 May 13.

Abstract

BACKGROUND

Childhood adversities are associated with an elevated risk for common mental disorders (CMDs). Whether the strength of the association also holds for young employees is unclear. Given the increase in CMD rates in young adults over the past decade, identification of risk factors has important implications for future public health interventions. The current study aimed to investigate the effects of childhood adversities on CMDs. Additionally, the role of occupational class (non-manual/manual workers) in the relationship was examined.

METHODS

This population-based longitudinal cohort study included 544,003 employees, 19-29 years, residing in Sweden in 2009. Adversities included parental death, parental mental and somatic disorders, parental separation or single-parent household, household public assistance and residential instability. Estimates of risk of CMDs, measured as prescription of antidepressants and/or psychiatric care with a clinical diagnosis of CMDs, between 2010 and 2016 were calculated as relative risks (RR) with 95% confidence intervals (CI), using a modified Poisson regression analysis. Occupational class (non-manual/manual workers) was explored as a potential moderator.

RESULTS

In both manual and non-manual workers, childhood adversities were associated with an elevated risk of subsequent CMDs. The risk was moderated by occupational class, i.e., especially pronounced risk was found in manual workers who had experienced cumulative adversity (adjusted RR 1.76, 95% CI 1.70-1.83) when compared to non-manual workers with no adversity. Among the adversities examined, having had a parent treated for a mental disorder, having grown up in a household living on public assistance or having experienced residential instability were the strongest predictors of CMDs.

CONCLUSION

Our findings suggest that, among young employees, manual workers with a history of multiple childhood adversities are especially vulnerable to subsequent CMDs.

摘要

背景

童年逆境与常见精神障碍(CMD)的风险增加有关。这种关联在年轻员工中的强度是否存在尚不清楚。鉴于过去十年中年轻人 CMD 发病率的增加,确定风险因素对于未来的公共卫生干预具有重要意义。本研究旨在探讨童年逆境对 CMD 的影响。此外,还研究了职业类别(非体力劳动者/体力劳动者)在这种关系中的作用。

方法

本基于人群的纵向队列研究纳入了 2009 年居住在瑞典的 544003 名 19-29 岁的员工。逆境包括父母死亡、父母精神和躯体障碍、父母离异或单亲家庭、家庭享受公共援助和居住不稳定。使用改良泊松回归分析,计算了 2010 年至 2016 年期间 CMD 风险(以抗抑郁药处方和/或临床诊断为 CMD 的精神科治疗估计)的相对风险(RR)及其 95%置信区间(CI)。职业类别(非体力劳动者/体力劳动者)被视为潜在的调节因素。

结果

在体力劳动者和非体力劳动者中,童年逆境与随后发生 CMD 的风险增加有关。这种风险由职业类别调节,即与无逆境的非体力劳动者相比,经历过累积逆境的体力劳动者(调整后的 RR 1.76,95%CI 1.70-1.83)的风险明显更高。在所研究的逆境中,有父母接受精神疾病治疗、在享受公共援助的家庭中长大或经历过居住不稳定的经历与 CMD 的相关性最强。

结论

我们的研究结果表明,在年轻员工中,有多次童年逆境史的体力劳动者尤其容易发生随后的 CMD。

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