Grupo de Nutrición, Facultad de Salud, Universidad del Valle, Calle 4B # 36-00, Edificio 116, Oficina 5002, Cali, Colombia.
Departamento de Cirugía/Urología, Escuela de Medicina, Universidad del Valle, Cali, Colombia.
Mol Biol Rep. 2020 Jun;47(6):4709-4721. doi: 10.1007/s11033-020-05503-6. Epub 2020 May 13.
Cervical cancer is the fourth most common cancer worldwide in women. Apoptosis reactivation has become the main strategy for decreasing cancer proliferation. There is a need to extend the search for new drugs to implement more effective and less toxic strategies for cervical cancer treatment. Research has been carried out to find new drugs that have minimal side effects and that focus on the tumor microenvironment, particularly in the induction of cellular apoptosis and cell migration and the inhibition of angiogenesis. Potent toxins from snake venoms have shown potential as sources for the synthesis of new drugs with such characteristics. The present work aimed to describe cervical cancer characteristics, associated risk factors, current treatments and to highlight the effects of toxins isolated from the venom of snakes of the Viperidae family on cervical cancer cell lines.
宫颈癌是全球女性中第四常见的癌症。凋亡再激活已成为减少癌症增殖的主要策略。需要扩大对新药的研究，以实施更有效和毒性更小的宫颈癌治疗策略。已经进行了研究，以寻找具有最小副作用的新药，这些新药特别侧重于肿瘤微环境，特别是在诱导细胞凋亡、细胞迁移和抑制血管生成方面。蛇毒液中的有效毒素已被证明是合成具有这些特性的新药的潜在来源。本工作旨在描述宫颈癌的特征、相关危险因素、现有治疗方法，并强调从蝰蛇科蛇毒中分离出的毒素对宫颈癌细胞系的影响。
