• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

儿科肾移植受者的轻度 COVID-19 感染。

Mild COVID-19 in a pediatric renal transplant recipient.

机构信息

Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

出版信息

Am J Transplant. 2020 Oct;20(10):2942-2945. doi: 10.1111/ajt.16003. Epub 2020 Jun 8.

DOI:10.1111/ajt.16003
PMID:32406181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7272978/
Abstract

As of mid-April 2020, the coronavirus disease of 2019 (COVID-19) pandemic has affected more than 2 million people and caused 135 000 deaths worldwide. Not much is known about the effect of this disease in immunosuppressed children with renal transplantation (RT). Here we report a 13-year-old child with multiple comorbidities who acquired COVID-19 5 years post-RT in the United States. Maintenance immunosuppression (IS) consisted of sirolimus and mycophenolate. There was no history of travel or exposure to sick contacts. The presenting features were fever, cough, rhinorrhea, and hypoxemia. Diarrhea was the only extrapulmonary manifestation. Chest X-ray was normal. He did not require intensive care unit care or ventilation. There was a transient rise in his serum creatinine without change in urine output; dialysis was not required. Slight reduction in IS was done. He had an excellent clinical recovery within 4 days and was able to be discharged home. His respiratory symptoms resolved but the diarrhea persisted during a 4-week follow-up period. This report provides a brief perspective on the short-term COVID-19 clinical course in an immunosuppressed child. More reports will add valuable information on the potential variety of spectrum of the illness in this subset of children.

摘要

截至 2020 年 4 月中旬,2019 年冠状病毒病(COVID-19)大流行已影响全球超过 200 万人,并导致 13.5 万人死亡。对于接受肾移植(RT)的免疫抑制儿童的这种疾病的影响,我们知之甚少。在此,我们报告了一名美国 13 岁的儿童,他在 RT 后 5 年感染了 COVID-19,且合并多种合并症。维持性免疫抑制(IS)由西罗莫司和霉酚酸酯组成。他没有旅行或接触患病接触者的病史。临床表现为发热、咳嗽、流涕和低氧血症。腹泻是唯一的肺外表现。胸部 X 线正常。他不需要重症监护或通气。他的血清肌酐一过性升高,但尿量没有变化;不需要透析。IS 略有减少。他在 4 天内临床恢复良好,并能够出院回家。他的呼吸道症状缓解,但腹泻在 4 周的随访期间持续存在。本报告简要介绍了免疫抑制儿童的 COVID-19 短期临床病程。更多的报告将提供有关该疾病在这组儿童中潜在的各种疾病谱的有价值信息。

相似文献

1
Mild COVID-19 in a pediatric renal transplant recipient.儿科肾移植受者的轻度 COVID-19 感染。
Am J Transplant. 2020 Oct;20(10):2942-2945. doi: 10.1111/ajt.16003. Epub 2020 Jun 8.
2
Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China.新型冠状病毒肺炎合并免疫抑制的肾移植受者肺炎:中国武汉 10 例确诊病例总结
Eur Urol. 2020 Jun;77(6):748-754. doi: 10.1016/j.eururo.2020.03.039. Epub 2020 Apr 18.
3
COVID-19 infection in kidney transplant recipients.肾移植受者中的 COVID-19 感染。
Kidney Int. 2020 Jun;97(6):1076-1082. doi: 10.1016/j.kint.2020.03.018. Epub 2020 Apr 9.
4
Early COVID-19 infection after lung transplantation.肺移植术后早期 COVID-19 感染。
Am J Transplant. 2020 Oct;20(10):2923-2927. doi: 10.1111/ajt.16097. Epub 2020 Jun 11.
5
Clinical Course, Imaging Features, and Outcomes of COVID-19 in Kidney Transplant Recipients.肾移植受者 COVID-19 的临床病程、影像学特征和转归。
Eur Urol. 2020 Aug;78(2):281-286. doi: 10.1016/j.eururo.2020.04.064. Epub 2020 May 6.
6
COVID-19 pneumonia in lung transplant recipients: Report of 2 cases.肺移植受者中的 COVID-19 肺炎:2 例报告。
Am J Transplant. 2020 Oct;20(10):2933-2937. doi: 10.1111/ajt.15993. Epub 2020 Jun 14.
7
A kidney transplant recipient with nausea, vomiting, and diarrhea after a recent COVID-19 exposure.一名肾移植受者近期接触新冠病毒后出现恶心、呕吐和腹泻症状。
Am J Transplant. 2020 Sep;20(9):2618-2620. doi: 10.1111/ajt.16184.
8
SARS-CoV-2 infection in two patients following recent lung transplantation.两例近期肺移植术后患者感染 SARS-CoV-2。
Am J Transplant. 2020 Oct;20(10):2928-2932. doi: 10.1111/ajt.15998. Epub 2020 Jul 22.
9
Uneventful case of COVID-19 in a kidney transplant recipient.一名肾移植受者的新冠病毒病(COVID-19)轻症病例。
BMJ Case Rep. 2020 Jul 20;13(7):e237427. doi: 10.1136/bcr-2020-237427.
10
Early experience of COVID-19 in 2 heart transplant recipients: Case reports and review of treatment options.COVID-19 在 2 例心脏移植受者中的早期经验:病例报告和治疗选择回顾。
Am J Transplant. 2020 Oct;20(10):2916-2922. doi: 10.1111/ajt.15982. Epub 2020 May 22.

引用本文的文献

1
COVID-19 in immunocompromised children and adolescents.免疫功能低下儿童和青少年的新冠病毒病
Clin Exp Pediatr. 2023 May;66(5):182-189. doi: 10.3345/cep.2022.00878. Epub 2023 Apr 18.
2
Co-infection of coronavirus disease 19 and cytomegalovirus in a kidney transplant recipient.一名肾移植受者中新型冠状病毒肺炎与巨细胞病毒的合并感染
Clin Case Rep. 2023 Mar 4;11(3):e7046. doi: 10.1002/ccr3.7046. eCollection 2023 Mar.
3
The clinical follow-up and management of COVID-19 in children and adolescents with an immunocompromised state or a malignancy.儿童和青少年免疫功能低下或患有恶性肿瘤的 COVID-19 的临床随访和管理。
Turk J Med Sci. 2022 Jun;52(3):571-579. doi: 10.55730/1300-0144.5348. Epub 2022 Jun 16.
4
Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience.埃及血液透析和肾移植儿童中的 COVID-19:单中心经验回顾性分析。
Ital J Pediatr. 2022 Aug 19;48(1):149. doi: 10.1186/s13052-022-01345-z.
5
Contributing factors to pediatric COVID-19 and MIS-C during the initial waves: A systematic review of 92 case reports.第一波疫情期间儿童新冠病毒感染及儿童多系统炎症综合征的促成因素:对92例病例报告的系统评价
Ann Med Surg (Lond). 2022 Sep;81:104227. doi: 10.1016/j.amsu.2022.104227. Epub 2022 Jul 31.
6
Covid-19 in kidney transplant recipients with immunosuppressive therapy.接受免疫抑制治疗的肾移植受者中的新冠病毒 19 感染情况。
Caspian J Intern Med. 2022;13(Suppl 3):161-172. doi: 10.22088/cjim.12.4.509.
7
Indications and Limitations of Sirolimus in the Treatment of Vascular Anomalies-Insights From a Retrospective Case Series.西罗莫司治疗血管异常的适应证及局限性——来自一项回顾性病例系列研究的见解
Front Pediatr. 2022 May 23;10:857436. doi: 10.3389/fped.2022.857436. eCollection 2022.
8
Pediatric transplantation during the COVID-19 pandemic.新冠疫情期间的儿科移植
World J Transplant. 2022 May 18;12(5):88-99. doi: 10.5500/wjt.v12.i5.88.
9
COVID-19 infection in pediatric solid organ transplant patients.儿童实体器官移植患者的 COVID-19 感染。
Pediatr Transplant. 2022 Mar;26(2):e14156. doi: 10.1111/petr.14156. Epub 2021 Oct 11.
10
Living with the virus: Infection and epidemiology of COVID-19 in hotspot area of India.与病毒共存:印度热点地区的新冠病毒感染与流行病学
J Public Aff. 2021 Nov;21(4):e2651. doi: 10.1002/pa.2651. Epub 2021 Feb 22.

本文引用的文献

1
First cases of COVID-19 in heart transplantation from China.中国心脏移植中首例新冠病毒病病例。
J Heart Lung Transplant. 2020 May;39(5):496-497. doi: 10.1016/j.healun.2020.03.006. Epub 2020 Mar 17.
2
COVID-19 infection in kidney transplant recipients.肾移植受者中的 COVID-19 感染。
Kidney Int. 2020 Jun;97(6):1076-1082. doi: 10.1016/j.kint.2020.03.018. Epub 2020 Apr 9.
3
Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study.中国湖北有消化道症状的 COVID-19 患者的临床特征:一项描述性、横断面、多中心研究。
Am J Gastroenterol. 2020 May;115(5):766-773. doi: 10.14309/ajg.0000000000000620.
4
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.新型冠状病毒病中“细胞因子风暴”的发病机制与治疗。
J Infect. 2020 Jun;80(6):607-613. doi: 10.1016/j.jinf.2020.03.037. Epub 2020 Apr 10.
5
Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic.冠状病毒与免疫抑制患者:第三次疫情期间的实际情况
Liver Transpl. 2020 Jun;26(6):832-834. doi: 10.1002/lt.25756. Epub 2020 Apr 24.
6
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2.基于网络的2019新型冠状病毒(2019-nCoV/SARS-CoV-2)药物重新利用研究
Cell Discov. 2020 Mar 16;6:14. doi: 10.1038/s41421-020-0153-3. eCollection 2020.
7
SARS-CoV-2 Infection in Children.儿童感染新型冠状病毒2型
N Engl J Med. 2020 Apr 23;382(17):1663-1665. doi: 10.1056/NEJMc2005073. Epub 2020 Mar 18.
8
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression.肾移植受者长期免疫抑制后 COVID-19 肺炎的成功康复。
Am J Transplant. 2020 Jul;20(7):1859-1863. doi: 10.1111/ajt.15869. Epub 2020 Mar 31.
9
Evidence for Gastrointestinal Infection of SARS-CoV-2.新型冠状病毒2019(SARS-CoV-2)胃肠道感染的证据。
Gastroenterology. 2020 May;158(6):1831-1833.e3. doi: 10.1053/j.gastro.2020.02.055. Epub 2020 Mar 3.
10
A Well Infant With Coronavirus Disease 2019 With High Viral Load.2019 年冠状病毒病的高病毒载量健康婴儿。
Clin Infect Dis. 2020 Jul 28;71(15):847-849. doi: 10.1093/cid/ciaa201.