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儿科肾移植受者的轻度 COVID-19 感染。

Mild COVID-19 in a pediatric renal transplant recipient.

机构信息

Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

Department of Pediatrics, University of Florida, Gainesville, Florida, USA.

出版信息

Am J Transplant. 2020 Oct;20(10):2942-2945. doi: 10.1111/ajt.16003. Epub 2020 Jun 8.

Abstract

As of mid-April 2020, the coronavirus disease of 2019 (COVID-19) pandemic has affected more than 2 million people and caused 135 000 deaths worldwide. Not much is known about the effect of this disease in immunosuppressed children with renal transplantation (RT). Here we report a 13-year-old child with multiple comorbidities who acquired COVID-19 5 years post-RT in the United States. Maintenance immunosuppression (IS) consisted of sirolimus and mycophenolate. There was no history of travel or exposure to sick contacts. The presenting features were fever, cough, rhinorrhea, and hypoxemia. Diarrhea was the only extrapulmonary manifestation. Chest X-ray was normal. He did not require intensive care unit care or ventilation. There was a transient rise in his serum creatinine without change in urine output; dialysis was not required. Slight reduction in IS was done. He had an excellent clinical recovery within 4 days and was able to be discharged home. His respiratory symptoms resolved but the diarrhea persisted during a 4-week follow-up period. This report provides a brief perspective on the short-term COVID-19 clinical course in an immunosuppressed child. More reports will add valuable information on the potential variety of spectrum of the illness in this subset of children.

摘要

截至 2020 年 4 月中旬,2019 年冠状病毒病(COVID-19)大流行已影响全球超过 200 万人,并导致 13.5 万人死亡。对于接受肾移植(RT)的免疫抑制儿童的这种疾病的影响,我们知之甚少。在此,我们报告了一名美国 13 岁的儿童,他在 RT 后 5 年感染了 COVID-19,且合并多种合并症。维持性免疫抑制(IS)由西罗莫司和霉酚酸酯组成。他没有旅行或接触患病接触者的病史。临床表现为发热、咳嗽、流涕和低氧血症。腹泻是唯一的肺外表现。胸部 X 线正常。他不需要重症监护或通气。他的血清肌酐一过性升高,但尿量没有变化;不需要透析。IS 略有减少。他在 4 天内临床恢复良好,并能够出院回家。他的呼吸道症状缓解,但腹泻在 4 周的随访期间持续存在。本报告简要介绍了免疫抑制儿童的 COVID-19 短期临床病程。更多的报告将提供有关该疾病在这组儿童中潜在的各种疾病谱的有价值信息。

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本文引用的文献

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First cases of COVID-19 in heart transplantation from China.中国心脏移植中首例新冠病毒病病例。
J Heart Lung Transplant. 2020 May;39(5):496-497. doi: 10.1016/j.healun.2020.03.006. Epub 2020 Mar 17.
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COVID-19 infection in kidney transplant recipients.肾移植受者中的 COVID-19 感染。
Kidney Int. 2020 Jun;97(6):1076-1082. doi: 10.1016/j.kint.2020.03.018. Epub 2020 Apr 9.
7
SARS-CoV-2 Infection in Children.儿童感染新型冠状病毒2型
N Engl J Med. 2020 Apr 23;382(17):1663-1665. doi: 10.1056/NEJMc2005073. Epub 2020 Mar 18.
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Evidence for Gastrointestinal Infection of SARS-CoV-2.新型冠状病毒2019(SARS-CoV-2)胃肠道感染的证据。
Gastroenterology. 2020 May;158(6):1831-1833.e3. doi: 10.1053/j.gastro.2020.02.055. Epub 2020 Mar 3.

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