新型冠状病毒病中“细胞因子风暴”的发病机制与治疗。
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.
机构信息
National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, No 3333, Binsheng Road, Hangzhou 310052, China.
National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, No 3333, Binsheng Road, Hangzhou 310052, China.
出版信息
J Infect. 2020 Jun;80(6):607-613. doi: 10.1016/j.jinf.2020.03.037. Epub 2020 Apr 10.
Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
细胞因子风暴是对外界刺激的过度免疫反应。细胞因子风暴的发病机制复杂，病情进展迅速，死亡率高。有一定证据表明，在 2019 冠状病毒病（COVID-19）流行期间，部分患者病情的急剧恶化与其体内的细胞因子风暴密切相关。本文就 COVID-19 病毒诱导的炎症风暴的发生机制和治疗策略进行综述，以期为临床治疗提供有价值的用药指导。
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