MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China.
J Biophotonics. 2020 Aug;13(8):e202000105. doi: 10.1002/jbio.202000105. Epub 2020 May 22.
Skin carcinoma such as melanoma (MM) and cutaneous squamous cell carcinoma (cSCC) are considered as the highest mortality and the most aggressive skin cancers in dermatology. In view that early diagnosis and treatment can greatly improve the survival rate and life quality of the patients, developing noninvasive and effective evaluation methods is of great significance for the detection and identification of early stage cutaneous cancers. In this article, we propose a hybrid photoacoustic and hyperspectral dual-modality microscopy to evaluate and differentiate skin carcinoma by structural and multiphysiological parameters. The proposed system's imaging abilities are verified by mimic phantoms and normal mice experiments. Furthermore, in vivo characterization and evaluation results of MM and cSCC mice are obtained successfully, which prove this novel method could be used as a reliable and useful method for skin cancer detection in early stages.
皮肤癌，如黑色素瘤（MM）和皮肤鳞状细胞癌（cSCC），被认为是皮肤科中死亡率最高和侵袭性最强的皮肤癌。鉴于早期诊断和治疗可以大大提高患者的生存率和生活质量，开发非侵入性和有效的评估方法对于早期皮肤癌的检测和识别具有重要意义。在本文中，我们提出了一种混合光声和高光谱双模态显微镜，通过结构和多生理参数来评估和区分皮肤癌。通过模拟体模和正常小鼠实验验证了所提出系统的成像能力。此外，还成功获得了 MM 和 cSCC 小鼠的体内特征化和评估结果，证明这种新方法可作为早期皮肤癌检测的可靠且有用的方法。
