Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha. (A.M.G., P.V.).
Department of Health Services Research and Administration, University of Nebraska Medical Center, Omaha. (H.J.T., L.-W.C.).
Circ Cardiovasc Interv. 2020 May;13(5):e008681. doi: 10.1161/CIRCINTERVENTIONS.119.008681. Epub 2020 May 14.
The number of patients treated for aortic valve disease in the United States is increasing rapidly. Transcatheter aortic valve replacement (TAVR) is supplanting surgical aortic valve replacement (SAVR) and medical therapy (MT). The economic implications of these trends are unknown. Therefore, we undertook to determine the costs, inpatient days, and number of admissions associated with treating aortic valve disease with SAVR, TAVR, or MT.
Using the Nationwide Readmissions Database, we identified patients with aortic valve disease admitted 2012 to 2016 for SAVR, TAVR, and disease symptoms (congestive heart failure, unstable angina, non-ST-elevation myocardial infarction, syncope). Patients not undergoing SAVR or TAVR were classified as receiving MT. Beginning with the index admission, we estimated inpatient costs, days, and admissions over 6 months.
Among 190 563 patients with aortic valve disease, the average aggregate 6-month inpatient costs were $59 743 for SAVR, $64 395 for TAVR, and $23 460 for MT. Mean index admission was longer for SAVR (10.0 days) than for TAVR (7.0 day) or MT (5.3 days), but the average number of unplanned readmission inpatient days was 2.0 for SAVR, 3.0 for TAVR, and 4.3 for MT; the average number of total admissions was 1.3 for SAVR, 1.5 for TAVR, and 1.7 for MT (<0.01 for all). TAVR index admission costs decreased over time to become similar to SAVR costs by 2016.
Aggregate costs were higher for TAVR than SAVR and were significantly more expensive than MT alone. However, TAVR costs decreased over time while SAVR and MT costs remained unchanged.
在美国,接受主动脉瓣疾病治疗的患者数量正在迅速增加。经导管主动脉瓣置换术(TAVR)正在取代主动脉瓣置换术(SAVR)和药物治疗(MT)。这些趋势的经济影响尚不清楚。因此,我们着手确定使用 SAVR、TAVR 或 MT 治疗主动脉瓣疾病的成本、住院天数和入院次数。
使用全国再入院数据库,我们确定了 2012 年至 2016 年期间因 SAVR、TAVR 和疾病症状(充血性心力衰竭、不稳定型心绞痛、非 ST 段抬高型心肌梗死、晕厥)入院的主动脉瓣疾病患者。未接受 SAVR 或 TAVR 的患者被归类为接受 MT。从索引入院开始,我们估计了 6 个月内的住院费用、天数和入院次数。
在 190563 例主动脉瓣疾病患者中,SAVR 的平均 6 个月住院总费用为 59743 美元,TAVR 为 64395 美元,MT 为 23460 美元。SAVR 的平均指数入院时间(10.0 天)长于 TAVR(7.0 天)或 MT(5.3 天),但计划外再入院住院天数的平均数量为 SAVR 为 2.0,TAVR 为 3.0,MT 为 4.3;SAVR 的平均总入院次数为 1.3,TAVR 为 1.5,MT 为 1.7(所有比较均<0.01)。TAVR 的指数入院费用随着时间的推移而降低,到 2016 年与 SAVR 费用相当。
TAVR 的总费用高于 SAVR,明显高于单独的 MT。然而,TAVR 的成本随着时间的推移而降低,而 SAVR 和 MT 的成本保持不变。