Guo Ling, Zhang Aihua, Xiong Jie
College of Electrical Engineering, Northwest University for Nationalities, Lanzhou, 730030, People's Republic of China.
College of Electrical and Information Engineering, Lanzhou University of Technology, Lanzhou, 730050, People's Republic of China.
IET Syst Biol. 2020 Jun;14(3):120-126. doi: 10.1049/iet-syb.2019.0086.
Four subtypes of breast cancer, luminal A, luminal B, basal-like, human epidermal growth factor receptor-enriched, have been identified based on gene expression profiles of human tumours. The goal of this study is to find whether the same groups' genes would exhibit different networks among the four subtypes. Differential expressed genes between each of the four subtypes and the normal samples were identified. The overlaps between the four groups of differentially expressed genes were used to construct regulations networks for each of the four subtypes. Univariate and multivariate Cox regressions were employed to test the genes in the four regulation networks. This study demonstrated that the common genes in four subtypes showed different regulation. Also, the hsa-miR-182 and decorin pair performs different functions among the four subtypes of breast cancer. The result indicated that heterogeneity of breast cancer is not only reflected in the different expression patterns among different genes, but also in the different regulatory networks of the same group of genes.
基于人类肿瘤的基因表达谱，已鉴定出四种乳腺癌亚型，即腔面A型、腔面B型、基底样型、人表皮生长因子受体富集型。本研究的目的是探究同一组基因在这四种亚型中是否会呈现出不同的网络。确定了四种亚型中的每一种与正常样本之间的差异表达基因。利用四组差异表达基因之间的重叠部分构建了四种亚型各自的调控网络。采用单变量和多变量Cox回归对四个调控网络中的基因进行检验。本研究表明，四种亚型中的共同基因表现出不同的调控。此外，hsa-miR-182和核心蛋白聚糖对在四种乳腺癌亚型中发挥不同的功能。结果表明，乳腺癌的异质性不仅体现在不同基因之间不同的表达模式上，还体现在同一组基因不同的调控网络中。
