饮食因素在实验性自身免疫性脑脊髓炎和多发性硬化中的作用：全面综述。
Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review.
机构信息
Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.
Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA/Institute of Molecular Medicine, The Feinstein Institute for Medical Research, Manhasset, NY, USA/Department of Neurology, Lenox Hill Hospital, New York, NY, USA.
出版信息
Mult Scler. 2021 Apr;27(4):494-502. doi: 10.1177/1352458520923955. Epub 2020 May 14.
BACKGROUND
Dietary intervention in multiple sclerosis carries potential therapeutic implications. While studies utilizing animal models of multiple sclerosis (MS) have demonstrated intriguing findings, well-designed clinical trials are few in number.
OBJECTIVE
The objective of this study is to review the animal model and clinical literature regarding dietary factors in experimental autoimmune encephalitis (EAE) and MS.
METHODS
This manuscript provides a comprehensive review of current animal model and clinical knowledge related to dietary factors in MS.
RESULTS
While there is currently little data for any specific diet in MS, there is growing evidence that certain dietary factors may influence the disease.
CONCLUSIONS
Definitive information regarding dietary factors as a modifiable risk factor in MS will require larger randomized clinical trials.
背景
饮食干预多发性硬化症具有潜在的治疗意义。虽然利用多发性硬化症（MS）动物模型的研究已经取得了有趣的发现，但精心设计的临床试验却很少。
目的
本研究旨在综述动物模型和临床文献中有关实验性自身免疫性脑脊髓炎（EAE）和多发性硬化症（MS）中饮食因素的研究。
方法
本文对 MS 中与饮食因素相关的现有动物模型和临床知识进行了全面综述。
结果
目前，针对 MS 中任何特定饮食的证据都很少，但越来越多的证据表明，某些饮食因素可能会影响疾病。
结论
关于饮食因素作为 MS 可改变的风险因素的明确信息，将需要更大规模的随机临床试验。
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