Laboratory of Genomics & Bioinformatics, Ludwik Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Gut Microbes. 2023 Dec;15(2):2274126. doi: 10.1080/19490976.2023.2274126. Epub 2023 Nov 18.
Multiple sclerosis (MS) causes long-lasting, multifocal damage to the central nervous system. The complex background of MS is associated with autoimmune inflammation and neurodegeneration processes, and is potentially affected by many contributing factors, including altered composition and function of the gut microbiota. In this review, current experimental and clinical evidence is presented for the characteristics of gut dysbiosis found in MS, as well as for its relevant links with the course of the disease and the dysregulated immune response and metabolic pathways involved in MS pathology. Furthermore, therapeutic implications of these investigations are discussed, with a range of pharmacological, dietary and other interventions targeted at the gut microbiome and thus intended to have beneficial effects on the course of MS.
多发性硬化症（MS）会导致中枢神经系统的持久、多灶性损伤。MS 的复杂背景与自身免疫炎症和神经退行性过程有关，并且可能受到许多影响因素的影响，包括肠道微生物群的组成和功能改变。在这篇综述中，提出了 MS 中发现的肠道菌群失调的特征的现有实验和临床证据，以及它与疾病进程以及涉及 MS 病理学的失调免疫反应和代谢途径的相关联系。此外，还讨论了这些研究的治疗意义，包括针对肠道微生物组的一系列药理学、饮食和其他干预措施，旨在对 MS 的病程产生有益影响。
