School of Life Sciences, Biomedical Pioneering Innovation Center (BIOPIC) & Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI) and State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing 100871, China.
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Nucleic Acids Res. 2020 Jul 2;48(W1):W230-W238. doi: 10.1093/nar/gkaa368.
With the abundant mammalian lncRNAs identified recently, a comprehensive annotation resource for these novel lncRNAs is an urgent need. Since its first release in November 2016, AnnoLnc has been the only online server for comprehensively annotating novel human lncRNAs on-the-fly. Here, with significant updates to multiple annotation modules, backend datasets and the code base, AnnoLnc2 continues the effort to provide the scientific community with a one-stop online portal for systematically annotating novel human and mouse lncRNAs with a comprehensive functional spectrum covering sequences, structure, expression, regulation, genetic association and evolution. In response to numerous requests from multiple users, a standalone package is also provided for large-scale offline analysis. We believe that updated AnnoLnc2 (http://annolnc.gao-lab.org/) will help both computational and bench biologists identify lncRNA functions and investigate underlying mechanisms.
随着最近大量哺乳动物 lncRNAs 的鉴定，迫切需要一个全面注释这些新型 lncRNAs 的资源。自 2016 年 11 月首次发布以来，AnnoLnc 一直是唯一在线服务器，用于实时全面注释新型人类 lncRNAs。在这里，通过对多个注释模块、后端数据集和代码库进行重大更新，AnnoLnc2 继续努力为科学界提供一个一站式在线门户，用于系统注释新型人类和小鼠 lncRNAs，涵盖序列、结构、表达、调控、遗传关联和进化等全面的功能谱。为了响应来自多个用户的大量请求，还提供了一个独立的软件包用于大规模离线分析。我们相信，更新后的 AnnoLnc2(http://annolnc.gao-lab.org/)将有助于计算生物学家和实验生物学家识别 lncRNA 的功能并研究潜在机制。
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