Chromosome and Plasmid Features of Two ST37 Strains Isolated in China Reveal Distinct Multidrug Resistance and Virulence Determinants.

ST37 is an emerging and prevalent multilocus sequence type and represents a lineage of clinical significance. This study aimed to characterize two epidemic ST37 strains, CD161 and CDT4. CD161 acquires a chromosome and two distinct plasmids, pCD161-L, sharing high similarity with phage, and pCD161-S, while CDT4 has a chromosome and a plasmid pCDT4 identical to pCD161-S. In the chromosome of both strains, three Cdt1-like elements and a skin element, which might influence sporulation, were identified. The multidrug resistance of the strains was due to the mutation in , , and genes and the acquisition of , , , and genes. In addition, a distinct pathogenicity locus (PaLoc) with truncated gene represents the genetic feature of ST37 strains. To our knowledge, this is the first complete genome, both chromosomes and plasmids, of epidemic ST37 strains in China.