School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Microb Drug Resist. 2020 Dec;26(12):1503-1508. doi: 10.1089/mdr.2019.0461. Epub 2020 May 14.
ST37 is an emerging and prevalent multilocus sequence type and represents a lineage of clinical significance. This study aimed to characterize two epidemic ST37 strains, CD161 and CDT4. CD161 acquires a chromosome and two distinct plasmids, pCD161-L, sharing high similarity with phage, and pCD161-S, while CDT4 has a chromosome and a plasmid pCDT4 identical to pCD161-S. In the chromosome of both strains, three Cdt1-like elements and a skin element, which might influence sporulation, were identified. The multidrug resistance of the strains was due to the mutation in , , and genes and the acquisition of , , , and genes. In addition, a distinct pathogenicity locus (PaLoc) with truncated gene represents the genetic feature of ST37 strains. To our knowledge, this is the first complete genome, both chromosomes and plasmids, of epidemic ST37 strains in China.
ST37 是一种新兴且流行的多位点序列型，代表了具有临床意义的谱系。本研究旨在对两种流行的 ST37 菌株 CD161 和 CDT4 进行特征描述。CD161 获得了一条染色体和两个截然不同的质粒 pCD161-L，与噬菌体具有高度相似性，以及 pCD161-S；而 CDT4 则拥有一条染色体和一个与 pCD161-S 相同的质粒 pCDT4。在这两个菌株的染色体中，鉴定出了三个 Cdt1 样元件和一个皮肤元件，这些元件可能影响孢子形成。这些菌株的多药耐药性是由于基因和基因的突变以及基因、基因、基因和基因的获得导致的。此外，一个截断的基因的独特致病性基因座 (PaLoc) 代表了 ST37 菌株的遗传特征。据我们所知，这是中国首次对流行的 ST37 菌株进行完整基因组（包括染色体和质粒）的测序。
