Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
Department of Medical Microbiology, The Infant Jesus Teaching Hospital, Warsaw, Poland.
Microb Drug Resist. 2020 Dec;26(12):1452-1457. doi: 10.1089/mdr.2019.0462. Epub 2020 May 14.
The aim of this study was to analyze the susceptibility of and spp. strains, isolated from patients hospitalized in the clinical hospital in Poland to penicillin, amoxicillin with clavulanic acid, imipenem, clindamycin, and metronidazole. We analyzed susceptibility of 476 isolates to routinely use for the treatment of anaerobic bacterial infections antibiotics. test method was used to determining the minimal inhibitory concentration values. To show the trend of drug resistance, we compared data from two periods within the years 2003-2017. Research results indicate that the problem of resistance is mainly related to strains belonging to non-fragilis . In the analyzed periods, there was an increase in the percentage of clindamycin-resistant isolates (35.21% vs. 53.33%), amoxicillin/clavulanic acid (2.83% vs. 8.15%), and imipenem (1.41% vs. 3.7%). In isolates belonging to , we observed a constant high (∼50%) percentage of clindamycin-resistant strains. The overwhelming majority of strains were resistant to penicillin (>95%) and about 20% of the isolates were not susceptible to clindamycin. Clindamycin, due to the high and increasing percentage of resistant strains, may not be a good choice in the empirical therapy of infections caused by and . Our study highlighted the importance of a routine or at least periodic monitoring of antimicrobial susceptibility of anaerobic Gram-negative bacilli, providing important information for appropriate therapy. The study shows that infection caused (or suspected of being caused) by and spp. can be empirically treated with metronidazole or imipenem.
本研究旨在分析从波兰临床医院住院患者中分离出的 和 spp. 菌株对青霉素、阿莫西林克拉维酸、亚胺培南、克林霉素和甲硝唑的敏感性。我们分析了 476 株分离株对常用于治疗厌氧细菌感染的抗生素的敏感性。采用 检测法测定最小抑菌浓度值。为了显示耐药趋势，我们比较了 2003-2017 年两个时期的数据。研究结果表明，耐药问题主要与非脆弱 菌株有关。在分析的两个时期内，克林霉素耐药分离株的百分比（35.21%比 53.33%）、阿莫西林/克拉维酸（2.83%比 8.15%）和亚胺培南（1.41%比 3.7%）均有所增加。在属于 的分离株中，我们观察到克林霉素耐药菌株的比例一直很高（约 50%）。绝大多数 菌株对青霉素耐药（>95%），约 20%的分离株对克林霉素不敏感。克林霉素由于耐药菌株的比例高且不断增加，可能不是治疗 和 感染的经验性治疗的理想选择。我们的研究强调了定期监测厌氧革兰氏阴性杆菌的抗菌药物敏感性的重要性，为合理治疗提供了重要信息。研究表明，由 或 引起（或疑似由 引起）的感染可以经验性地用甲硝唑或亚胺培南治疗。
