Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 223, 69120 Heidelberg, Germany and Institute of Inorganic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 223, 69120 Heidelberg, Germany.
Dalton Trans. 2020 Jun 9;49(22):7294-7298. doi: 10.1039/d0dt01084g.
Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and 99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imaging in vitro. Importantly, the novel in- aqueous-solution-stable, functionalized Si-rhodamines retain favourable optical properties after complexation (QY = 0.09, λabs = 654 nm, λem = 669 nm in PBS) and show promising near-infrared optical properties for potential in vivo applications enabling bimodal scintigraphic imaging and optical imaging, e.g. used in radio- and fluorescence-guided tumour resection.
荧光硅罗丹明被修饰以与 Re(i)-和 99mTc(i)-三羰基核心配位。相应的配合物表现出作为 SPECT 和光学成像的双模式成像探针的合适性质，可用于体外。重要的是，新型在水溶液中稳定的、功能化的硅罗丹明在配位后保留了有利的光学性质（在 PBS 中 QY = 0.09、λabs = 654nm、λem = 669nm），并且显示出有前途的近红外光学性质，可用于潜在的体内应用，例如用于放射性和荧光引导的肿瘤切除的双模式闪烁成像和光学成像。
