Godard Amélie, Kalot Ghadir, Pliquett Jacques, Busser Benoit, Le Guével Xavier, Wegner K David, Resch-Genger Ute, Rousselin Yoann, Coll Jean-Luc, Denat Franck, Bodio Ewen, Goze Christine, Sancey Lucie
Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 21078 Dijon, France.
Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France.
Bioconjug Chem. 2020 Apr 15;31(4):1088-1092. doi: 10.1021/acs.bioconjchem.0c00175. Epub 2020 Apr 6.
A simple NIR-II emitting water-soluble system has been developed and applied and . , the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
一种简单的发射近红外二区光的水溶性体系已被开发并应用。该荧光团能快速在二维和三维细胞培养物中积累，并迅速到达啮齿动物体内的肿瘤，在长达1周的时间内显示出高近红外二区对比度。这种非常有效的探针具备向临床转化以及开发发射近红外二区光材料所需的所有特性。
