Pellegrino Robert, Cooper Keiland W, Di Pizio Antonella, Joseph Paule V, Bhutani Surabhi, Parma Valentina
Department of Food Science, Institute of Agriculture, University of Tennessee, Knoxville, TN, USA.
Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Chem Senses. 2020 May 14. doi: 10.1093/chemse/bjaa031.
A wealth of rapidly evolving reports suggests that olfaction and taste disturbances may be manifestations of the novel COVID-19 pandemic. While otolaryngological societies worldwide have started to consider chemosensory evaluation as a screening tool for COVID-19 infection, the true nature of the relationship between the changes in chemosensory ability and COVID-19 is unclear. Our goal with this review is to provide a brief overview of published and archived literature, as well as the anecdotal reports and social trends related to this topic up to April 29, 2020. We also aim to draw parallels between the clinical/chemosensory symptomology reported in association to past coronavirus pandemics (such as SARS and MERS) and the novel COVID-19. This review also highlights current evidence on persistent chemosensory disturbances after the infection has resolved. Overall, our analysis pinpoints the need for further studies: 1) to better quantify olfaction and taste disturbances associated with SARS-CoV-2 infection, compared to those of other viral and respiratory infections, 2) to understand the relation between smell, taste, and chemesthesis disturbances in COVID-19, and 3) to understand how persistent are these disturbances after the infection has resolved.
大量快速发展的报告表明，嗅觉和味觉障碍可能是新型冠状病毒肺炎大流行的表现。虽然全球耳鼻喉科学会已开始将化学感觉评估作为新冠病毒感染的筛查工具，但化学感觉能力变化与新冠病毒之间关系的真正性质尚不清楚。我们撰写这篇综述的目的是简要概述截至2020年4月29日已发表和存档的文献，以及与该主题相关的轶事报告和社会趋势。我们还旨在比较过去冠状病毒大流行（如非典和中东呼吸综合征）相关的临床/化学感觉症状与新型冠状病毒肺炎的症状。这篇综述还强调了感染消退后持续性化学感觉障碍的现有证据。总体而言，我们的分析指出需要进一步开展研究：1）与其他病毒和呼吸道感染相比，更好地量化与严重急性呼吸综合征冠状病毒2感染相关的嗅觉和味觉障碍；2）了解新冠病毒肺炎中嗅觉、味觉和化学感觉障碍之间的关系；3）了解感染消退后这些障碍的持续时间。
