Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
Trends Plant Sci. 2020 Jun;25(6):604-617. doi: 10.1016/j.tplants.2020.01.009. Epub 2020 Mar 19.
Calcium (Ca) serves as an essential nutrient as well as a signaling agent in all eukaryotes. In plants, calcineurin B-like proteins (CBLs) are a unique group of Ca sensors that decode Ca signals by activating a family of plant-specific protein kinases known as CBL-interacting protein kinases (CIPKs). Interactions between CBLs and CIPKs constitute a signaling network that enables information integration and physiological coordination in response to a variety of extracellular cues such as nutrient deprivation and abiotic stresses. Studies in the past two decades have established a unified paradigm that illustrates the functions of CBL-CIPK complexes in controlling membrane transport through targeting transporters and channels in the plasma membrane and tonoplast.
钙（Ca）作为一种必需的营养物质，也是所有真核生物的信号转导剂。在植物中，钙调神经磷酸酶 B 样蛋白（CBLs）是一组独特的 Ca 传感器，通过激活一组称为 CBL 相互作用蛋白激酶（CIPKs）的植物特异性蛋白激酶来解码 Ca 信号。CBLs 和 CIPKs 之间的相互作用构成了一个信号网络，使植物能够对外界刺激（如营养缺乏和非生物胁迫）做出响应，从而实现信息整合和生理协调。在过去的二十年中，研究已经建立了一个统一的范例，说明了 CBL-CIPK 复合物通过靶向质膜和液泡膜中的转运体和通道来控制膜转运的功能。
