胰岛素在色胺诱导的小鼠低血糖中的作用。
The involvement of insulin in tryptamine-induced hypoglycemia in mice.
作者信息
Sugimoto Y, Kimura I, Yamada J, Watanabe Y, Takeuchi N, Horisaka K
机构信息
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
出版信息
Life Sci. 1991;48(17):1679-83. doi: 10.1016/0024-3205(91)90128-x.
The effects of tryptamine on plasma glucose and serum insulin levels were studied in mice. Tryptamine elicited dose-dependent hypoglycemia and hyperinsulinemia in intact mice. In streptozotocin-diabetic mice, tryptamine did not change plasma glucose nor serum insulin levels. Tryptamine significantly inhibited glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. These results indicate that tryptamine-induced hypoglycemia is brought on by its releasing effects of insulin.
在小鼠中研究了色胺对血浆葡萄糖和血清胰岛素水平的影响。色胺在完整小鼠中引起剂量依赖性低血糖和高胰岛素血症。在链脲佐菌素诱导的糖尿病小鼠中，色胺未改变血浆葡萄糖和血清胰岛素水平。色胺显著抑制葡萄糖诱导的高血糖，并增强葡萄糖引起的胰岛素释放。这些结果表明，色胺诱导的低血糖是由其胰岛素释放作用引起的。
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