Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Diabetes Res Clin Pract. 2020 Jun;164:108200. doi: 10.1016/j.diabres.2020.108200. Epub 2020 May 12.
Since December 2019, a new strain ofcoronavirus named 2019 novel coronavirus (2019-nCoV) has been discovered in Wuhan. The prevalence of diabetes mellitus, which is a great public health issue leading to immunity inhibition and anincreased incidenceofinfections, has been increasing over the past ten years. The aim of this research was to systematically assess the prevalence of diabetes mellitus among 2019-nCoV.
We searched PubMed, Embase, Web of Science and Medline for observational studies up to February 25, 2020. A random effects model or fixed-effects model was applied to evaluate the pooled prevalence of diabetes mellitus and odds ratio (OR) with 95% confidence interval (CI).
In total, nine papers met the eligibility criteria. The pooled prevalence of DM was 9% (95% CI 6%-12%). There was obvious heterogeneity (I 65%, p = 0.004) in the prevalence of DM in these studies. The prevalence of DM in moderate patients with 2019-nCoV was 7% (95% CI 4%-10%). The prevalence of DM in severe patients with 2019-nCoV was 17% (95% CI 13%-21%). The prevalence of DM in severe patients with 2019-nCoV was significantly higher than that in moderate patients with 2019-nCoV (OR 2.49, 95% CI 1.70 to 3.64).
To our knowledge, this work is the first report showing the prevalence of diabetes mellitus in patients with 2019-nCoV, which is beneficial to prevent the spread of 2019-nCoV in the future.
自 2019 年 12 月以来，一种名为 2019 年新型冠状病毒（2019-nCoV）的新型冠状病毒已在武汉被发现。糖尿病的流行是一个重大的公共卫生问题，导致免疫抑制和感染发生率增加，在过去十年中一直在增加。本研究旨在系统评估 2019-nCoV 患者中糖尿病的患病率。
我们检索了PubMed、Embase、Web of Science 和 Medline 上截至 2020 年 2 月 25 日的观察性研究。应用随机效应模型或固定效应模型评估糖尿病的合并患病率和优势比（OR）及其 95%置信区间（CI）。
共有 9 篇论文符合入选标准。DM 的合并患病率为 9%（95%CI 6%-12%）。这些研究中 DM 的患病率存在明显的异质性（I 65%，p=0.004）。2019-nCoV 中度患者的 DM 患病率为 7%（95%CI 4%-10%）。2019-nCoV 重症患者的 DM 患病率为 17%（95%CI 13%-21%）。2019-nCoV 重症患者的 DM 患病率明显高于 2019-nCoV 中度患者（OR 2.49，95%CI 1.70 至 3.64）。
据我们所知，这是第一项报告 2019-nCoV 患者中糖尿病患病率的研究，有助于今后预防 2019-nCoV 的传播。
