Hehar Jaspreet, Todter Erika, Lahiri Sharon W
Department of Internal Medicine, Division of Endocrinology, Diabetes, Bone and Mineral Disorders, Henry Ford Health System, Detroit, MI.
Department of Public Health Sciences, Henry Ford Health System, Detroit, MI.
Clin Diabetes. 2022 Spring;40(2):141-152. doi: 10.2337/cd21-0065. Epub 2022 Apr 15.
Identification of specific risk factors for severe coronavirus disease 2019 (COVID-19) is crucial for prevention of poor outcomes and mortality. This retrospective cohort study of patients hospitalized with COVID-19 demonstrated that older age, male sex, Black race, diabetes, elevated BMI, and elevated inflammatory markers were correlated with critical illness in COVID-19. Older age, male sex, diabetes, and inflammatory markers, but not elevated BMI, were associated with mortality. Despite having greater odds of critical illness, Black patients had lower odds of death than White patients. Older age, male sex, diabetes, and elevated inflammatory markers were significantly associated with venous thromboembolism. These findings suggest a need to aggressively identify and manage modifiable risk factors (i.e., diabetes and elevated BMI) and encourage vaccination of at-risk individuals to prevent poor outcomes from COVID-19.
确定2019冠状病毒病（COVID-19）重症的特定风险因素对于预防不良结局和死亡至关重要。这项针对COVID-19住院患者的回顾性队列研究表明，高龄、男性、黑人种族、糖尿病、BMI升高和炎症标志物升高与COVID-19危重症相关。高龄、男性、糖尿病和炎症标志物与死亡率相关，但BMI升高与死亡率无关。尽管黑人患者患危重症的几率更高，但与白人患者相比，其死亡几率更低。高龄、男性、糖尿病和炎症标志物升高与静脉血栓栓塞显著相关。这些发现表明，有必要积极识别和管理可改变的风险因素（即糖尿病和BMI升高），并鼓励高危人群接种疫苗，以预防COVID-19的不良结局。
