Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai - 400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai - 400056, India..
Life Sci. 2020 Aug 1;254:117777. doi: 10.1016/j.lfs.2020.117777. Epub 2020 May 11.
Inflammatory cascade and oxidative stress play a central role in diabetic peripheral neuropathy via activation of inflammatory cytokines. Escin has potent antioxidant and anti-inflammatory properties. Hence, the present study was conducted to evaluate the effect of escin on diabetic peripheral neuropathy in streptozotocin (STZ) induced diabetes in rats.
Diabetes was induced in rats with streptozotocin (55 mg/kg). The animals with blood glucose above 250 mg/dl were randomized in different groups. Animals were treated with escin at a dose of 5, 10 and 20 mg/kg after six weeks of diabetes induction for the next four weeks. After completion of treatment, various parameters like glucose, thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia and nerve conduction velocities were evaluated. Oxidative stress parameters like malondialdehyde, catalase, reduced glutathione and superoxide dismutase were performed in sciatic nerves. Histopathology study of sciatic nerves was also studied.
Escin treatment significantly reduced plasma glucose, thermal hyperalgesia, mechanical hyperalgesia and mechanical allodynia as compared to diabetic animals. The motor nerve conduction velocity and sensory nerve conduction velocities were significantly improved in diabetic animals treated with escin. Escin significantly normalized oxidative stress parameters. Escin treatment also prevented progression of neuronal damage by reducing demyelination, leukocytic infiltration in sciatic nerves as compared to diabetic animals.
From the results of study it can be concluded that escin can be a useful option for management of diabetic peripheral neuropathy.
炎症级联和氧化应激通过激活炎症细胞因子在糖尿病周围神经病变中起核心作用。秦皮素具有强大的抗氧化和抗炎特性。因此，本研究旨在评估秦皮素对链脲佐菌素（STZ）诱导的糖尿病大鼠糖尿病周围神经病变的影响。
用链脲佐菌素（55mg/kg）诱导大鼠糖尿病。血糖高于 250mg/dl 的动物随机分为不同组。在糖尿病诱导 6 周后，动物用秦皮素以 5、10 和 20mg/kg 的剂量治疗 4 周。治疗完成后，评估各种参数，如血糖、热痛觉过敏、机械性痛觉过敏、机械性痛觉过敏和神经传导速度。还在坐骨神经中进行氧化应激参数，如丙二醛、过氧化氢酶、还原型谷胱甘肽和超氧化物歧化酶的测定。坐骨神经的组织病理学研究也进行了研究。
与糖尿病动物相比，秦皮素治疗显著降低了血浆葡萄糖、热痛觉过敏、机械性痛觉过敏和机械性痛觉过敏。秦皮素治疗的糖尿病动物的运动神经传导速度和感觉神经传导速度显著提高。秦皮素显著正常化氧化应激参数。秦皮素治疗还通过减少脱髓鞘和白细胞浸润来防止坐骨神经中神经元损伤的进展，与糖尿病动物相比。
从研究结果可以得出结论，秦皮素可能是治疗糖尿病周围神经病变的一种有用选择。
