Jarrett R J, Shipley M J
Division of Community Health, United Medical School, Guy's Hospital, U.K.
Diabetologia. 1988 Oct;31(10):737-40. doi: 10.1007/BF00274775.
Fifteen year mortality rates are reported for men participating in the Whitehall Study in 1968-70. Subjects were divided into four groups normoglycaemic (centiles 1-95 of the blood glucose distribution: n = 17,051), glucose intolerant (centiles 96-100: n = 999), newly diagnosed diabetic patients (n = 56) and previously diagnosed diabetic patients (n = 121) treated with diet +/- tablets. Relative risks for all causes mortality and from coronary and cardiovascular disease deaths were calculated. Age adjusted relative risks were highest in the newly diagnosed diabetic patients and were also increased in glucose intolerant and previously diagnosed diabetic men (p less than 0.05), but did not increase with increasing duration of diabetes. With adjustment for other risk factors, relative risks were similar in newly diagnosed and previously diagnosed diabetic men. There was no significant linear trend of adjusted relative risks with duration of diabetes when all diabetic men were pooled and person years at risk calculated. The lack of effect of duration upon relative risk together with other observations suggests common, possibly genetic, antecedents of both Type 2 (non-insulin-dependent) diabetes and coronary heart disease.
报告了1968 - 1970年参与白厅研究的男性的15年死亡率。研究对象被分为四组：血糖正常者（血糖分布百分位数1 - 95：n = 17,051）、糖耐量受损者（百分位数96 - 100：n = 999）、新诊断的糖尿病患者（n = 56）以及接受饮食 +/- 片剂治疗的既往诊断的糖尿病患者（n = 121）。计算了各种原因死亡率以及冠心病和心血管疾病死亡的相对风险。年龄调整后的相对风险在新诊断的糖尿病患者中最高，在糖耐量受损和既往诊断的糖尿病男性中也有所增加（p < 0.05），但并未随糖尿病病程的延长而增加。在调整其他风险因素后，新诊断和既往诊断的糖尿病男性的相对风险相似。当将所有糖尿病男性合并并计算风险人年时，调整后的相对风险与糖尿病病程之间没有显著的线性趋势。糖尿病病程对相对风险缺乏影响以及其他观察结果表明，2型（非胰岛素依赖型）糖尿病和冠心病可能有共同的、可能是遗传的病因。
