Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Assam 781039, India.
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER, Guwahati), Assam 781125, India.
Molecules. 2020 May 12;25(10):2278. doi: 10.3390/molecules25102278.
According to the World Health Organization (WHO), cancer is the second-highest cause of mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the disease, poor prognosis, cost of conventional therapies, and associated side-effects add more burden to patients, post-diagnosis. Therefore, the search for alternatives for the treatment of cancer that are safe, multi-targeted, effective, and cost-effective has compelled us to go back to ancient systems of medicine. Natural herbs and plant formulations are laden with a variety of phytochemicals. One such compound is rhein, which is an anthraquinone derived from the roots of spp. and . In ethnomedicine, these plants are used for the treatment of inflammation, osteoarthritis, diabetes, and bacterial and helminthic infections. Increasing evidence suggests that this compound can suppress breast cancer, cervical cancer, colon cancer, lung cancer, ovarian cancer, etc. in both in vitro and in vivo settings. Recent studies have reported that this compound modulates different signaling cascades in cancer cells and can prevent angiogenesis and progression of different types of cancers. The present review highlights the cancer-preventing and therapeutic properties of rhein based on the available literature, which will help to extend further research to establish the chemoprotective and therapeutic roles of rhein compared to other conventional drugs. Future pharmacokinetic and toxicological studies could support this compound as an effective anticancer agent.
根据世界卫生组织（WHO）的数据，癌症是全球第二大死亡原因，每年导致近 960 万人死亡。除了疾病的致命性、预后不良、传统疗法的成本以及相关副作用给患者带来的额外负担之外。因此，寻找安全、多靶点、有效且具有成本效益的癌症治疗替代方法迫使我们回归古代医学体系。天然草药和植物制剂中含有多种植物化学物质。一种这样的化合物是大黄酸，它是一种蒽醌，来源于 和 的根。在民族医学中，这些植物被用于治疗炎症、骨关节炎、糖尿病以及细菌和寄生虫感染。越来越多的证据表明，这种化合物可以抑制乳腺癌、宫颈癌、结肠癌、肺癌、卵巢癌等。在体外和体内环境中。最近的研究报告称，这种化合物可以调节癌细胞中的不同信号级联，并且可以预防不同类型癌症的血管生成和进展。本综述根据现有文献强调了大黄酸的抗癌和治疗特性，这将有助于进一步研究，以确定大黄酸与其他传统药物相比的化学预防和治疗作用。未来的药代动力学和毒理学研究可能会支持这种化合物作为一种有效的抗癌药物。
