Shah Chirag, Ouhib Zoubir, Kamrava Mitchell, Koyfman Shlomo A, Campbell Shauna R, Bhatnagar Ajay, Canavan Joycelin, Husain Zain, Barker Christopher A, Cohen Gil'ad N, Strasswimmer John, Joshi Nikhil
Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL.
Brachytherapy. 2020 Jul-Aug;19(4):415-426. doi: 10.1016/j.brachy.2020.04.004. Epub 2020 May 11.
Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs.
Physicians and physicists with expertise in skin cancer and brachytherapy created a consensus statement for appropriate patient selection, data, dosimetry, and utilization of skin brachytherapy and techniques based on a literature search and clinical experience.
Guidelines for patient selection, evaluation, and dose/fractionation schedules to optimize outcomes for patients with KC undergoing brachytherapy are presented. Studies of electronic brachytherapy are emerging, although limited long-term data or comparative data are available. Radionuclide-based brachytherapy represents an appropriate option for patients with small KCs with multiple techniques available.
Skin brachytherapy represents a standard of care option for appropriately selected patients with KC. Radionuclide-based brachytherapy represents a well-established technique; however, the current recommendation is that electronic brachytherapy be used for KC on prospective clinical trial or registry because of a paucity of mature data.
角质形成细胞癌（KC，以前称为非黑色素瘤皮肤癌）是全球最常见的癌症。虽然手术治疗是常用的方法，但也有多种放射治疗技术可供选择，包括外照射和近距离放射治疗。因此，美国近距离放射治疗学会针对近距离放射治疗在KC治疗中的应用制定了一份更新的共识声明。
具有皮肤癌和近距离放射治疗专业知识的医生和物理学家基于文献检索和临床经验，就皮肤近距离放射治疗的合适患者选择、数据、剂量测定以及技术的使用制定了一份共识声明。
本文提出了针对接受近距离放射治疗的KC患者进行患者选择、评估以及剂量/分割方案的指南，以优化治疗效果。电子近距离放射治疗的研究正在兴起，不过长期数据或比较数据有限。基于放射性核素的近距离放射治疗对患有小面积KC的患者来说是一种合适的选择，有多种技术可供使用。
皮肤近距离放射治疗是为合适的KC患者选择的一种标准治疗方案。基于放射性核素的近距离放射治疗是一种成熟的技术；然而，目前的建议是，由于缺乏成熟数据，电子近距离放射治疗应在前瞻性临床试验或登记研究中用于KC治疗。
