University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille (CIIL), Lille, France.
Laboratoire Virologie et Pathologie Humaine - VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Commun Biol. 2020 May 14;3(1):237. doi: 10.1038/s42003-020-0965-6.
Like all obligate intracellular pathogens, influenza A virus (IAV) reprograms host cell's glucose and lipid metabolism to promote its own replication. However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has not been yet characterized. Here, we show that influenza infection induces alterations in whole-body glucose metabolism that persist long after the virus has been cleared. We report depot-specific changes in the WAT of IAV-infected mice, notably characterized by the appearance of thermogenic brown-like adipocytes within the subcutaneous fat depot. Importantly, viral RNA- and viral antigen-harboring cells are detected in the WAT of infected mice. Using in vitro approaches, we find that IAV infection enhances the expression of brown-adipogenesis-related genes in preadipocytes. Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, metabolism and immunity, may play in influenza infection.
与所有专性细胞内病原体一样，甲型流感病毒（IAV）会重新编程宿主细胞的葡萄糖和脂质代谢，以促进自身复制。然而，流感感染对白色脂肪组织（WAT）的影响，WAT 是控制全身能量平衡的关键组织，尚未得到明确描述。在这里，我们表明流感感染会引起全身葡萄糖代谢的改变，即使在病毒清除后很长时间仍会持续。我们报告了 IAV 感染小鼠 WAT 的特定部位变化，特别是特征在于皮下脂肪组织中出现了产热棕色样脂肪细胞。重要的是，在感染小鼠的 WAT 中检测到了携带病毒 RNA 和病毒抗原的细胞。通过体外方法，我们发现 IAV 感染可增强前体脂肪细胞中棕色脂肪生成相关基因的表达。总的来说，我们的研究结果揭示了白色脂肪组织在流感感染中可能发挥的作用，该组织位于营养、代谢和免疫的交汇点。
