Center for Outcomes Research and Evaluation, McGill University Health Center-Research Institute, 5252 de Maisonneuve 2C.11, Montreal, QC, H4A 3S5, Canada.
School of Physical and Occupational Therapy, McGill University, Montreal, Canada.
Qual Life Res. 2020 Sep;29(9):2311-2332. doi: 10.1007/s11136-020-02519-0. Epub 2020 May 14.
In the context of identifying consequences and evaluating interventions for rare diseases, health-related quality of life (HRQL) measures are often used. Conclusions about HRQL are difficult to make as the participants are likely drawn from different countries. A global estimate of HRQL with estimates of variation would permit pooling of data from diverse sources. The aim was to estimate a global HRQL score of typically developing children and adolescents on the Pediatric Quality of Life Inventory (PedsQL™) and to identify sources of variation across studies.
A systematic search was conducted in December 2018 on four databases: MEDLINE, EMBASE, CINAHL and PsycINFO. Inclusion criteria were all population health studies or validation studies using the self-report version of the PedsQL™ for typically developing children aged 5 to 18 years. Quality appraisal was conducted using the Appraisal Tool for Cross-Sectional Studies. Meta-analysis and meta-regression were conducted.
A total of 66 studies with a sample size of 67,805 participants were included in this analysis. The average QOL score across all studies was 80.9 (CI 78.6-83.2). Univariate analyses showed that region, minimum age of sample and income of country, was associated with the total HRQL score. Subgroup analysis showed that there was an effect of age and region on HRQL scores.
Results of this review provide ranges of pediatric HRQL across personal factors and regions that can be used for normative comparisons of HRQL. Interpretation of scores on generic measures should always take into consideration the contextual influences in the child's life.
PROSPERO, CRD42019128313 https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019128313 .
在确定罕见病的后果和评估干预措施的背景下，通常使用健康相关生活质量（HRQL）测量。由于参与者可能来自不同的国家，因此很难得出关于 HRQL 的结论。对 HRQL 进行全球估计，并对其变异进行估计，可以允许从不同来源汇总数据。目的是估计典型发育儿童和青少年在儿科生活质量量表（PedsQL™）上的全球 HRQL 评分，并确定研究之间变异的来源。
2018 年 12 月，在四个数据库中进行了系统检索：MEDLINE、EMBASE、CINAHL 和 PsycINFO。纳入标准为所有使用 PedsQL™自评版的人群健康研究或验证研究，研究对象为 5 至 18 岁的典型发育儿童。使用横断面研究评估工具进行质量评估。进行了荟萃分析和荟萃回归分析。
共纳入 66 项研究，样本量为 67805 名参与者。所有研究的平均 QOL 评分均为 80.9（CI 78.6-83.2）。单变量分析表明，区域、样本最小年龄和国家收入与总 HRQL 评分相关。亚组分析表明，年龄和区域对 HRQL 评分有影响。
本综述的结果提供了儿童 HRQL 在个人因素和地区方面的范围，可用于 HRQL 的规范比较。对通用量表的评分进行解释时，应始终考虑到儿童生活中的背景影响。
PROSPERO，CRD42019128313 https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019128313。
