Peng Tianli, Li Zhi-Ming, Liu Jinjin, Zhang Yi
Department of Dermatology, The First Affiliated Hospital of WenZhou Medical University, WenZhou, China.
Dermatol Ther. 2020 Jul;33(4):e13584. doi: 10.1111/dth.13584. Epub 2020 Jul 6.
To evaluate the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) in patients with acne. Three hundred acne patients were enrolled from January 2019 to December 2019. PHQ-9 and Hamilton Depression Scale(HAMD) survey was conducted to evaluate their depression status. Cronbach's α coefficient and test-retest reliability after 1 week were used to analyze the reliability of PHQ-9. Factor analysis, Spearman correlation analysis, receiver operating characteristic curve (ROC curve) were used for validity analysis of the PHQ-9.The screening validity was analyzed in different subgroups. Two hundred fifty-eight patients with acne completed the questionnaire. Forty-seven were diagnosed with depressive disorder. The best cut-off point for the PHQ-9 score is 9 points, with a sensitivity of 95.7%,a specificity of 88.6% and the area under the ROC curve(AUC) of 0.973.In validity analysis, the correlation coefficient between the total score of PHQ-9 and HAMD was 0.766,the kappa value was 0.530.Factor analysis revealed two common factors (cognitive-affective factor and somatic symptom factor),which explained 65.52% of the total variances. In reliability analysis, the Cronbach's α coefficient of the PHQ-9 was 0.851,the test-retest reliability value was 0.824.The time to complete the PHQ-9 was significantly less than the time to complete HAMD (P < .001).The PHQ-9 shows good reliability and validity for the diagnosis of depression in patients with acne, and can be used for preliminary screening of depression.
评估患者健康问卷-9（PHQ-9）在痤疮患者中的信度和效度。2019年1月至2019年12月招募了300例痤疮患者。采用PHQ-9和汉密尔顿抑郁量表（HAMD）调查来评估他们的抑郁状态。使用Cronbach's α系数和1周后的重测信度来分析PHQ-9的信度。采用因子分析、Spearman相关分析、受试者工作特征曲线（ROC曲线）对PHQ-9进行效度分析。在不同亚组中分析筛查效度。258例痤疮患者完成了问卷。47例被诊断为抑郁症。PHQ-9评分的最佳切点为9分，灵敏度为95.7%，特异度为88.6%，ROC曲线下面积（AUC）为0.973。在效度分析中，PHQ-9总分与HAMD的相关系数为0.766，kappa值为0.530。因子分析显示两个共同因子（认知情感因子和躯体症状因子），解释了总方差的65.52%。在信度分析中，PHQ-9的Cronbach's α系数为0.851，重测信度值为0.824。完成PHQ-9的时间显著少于完成HAMD的时间（P<0.001）。PHQ-9在痤疮患者抑郁诊断中显示出良好的信度和效度，可用于抑郁症的初步筛查。
