The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People's Republic of China; Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.
Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China; School of Public Health, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Asian J Psychiatr. 2022 Jul;73:103104. doi: 10.1016/j.ajp.2022.103104. Epub 2022 Apr 6.
The objective of this research was to verify the psychometric characteristics of the Chinese Adaptation of self-report HAMD-6.
Outpatients and inpatients who met the DSM-5 criterion for major depressive disorder (MDD) were evaluated by the Chinese self-report HAMD-6, seventeen items of Hamilton Depression Rating Scale (HAMD-17), Patient Health Questionnaire Depression Scale (PHQ-9) and Improved Clinical Global Impression Scale (iCGI-S). The internal consistency reliability, retest reliability, criterion validity and construct validity of the Chinese self-report HAMD-6 were tested. Pearson correlation coefficient was used to assess the correlativity between the total score and the item scores. By drawing the Receiver Operating Characteristics (ROC) curve, the best cut-off value, sensitivity and specificity of Chinese Adaptation self-report HAMD-6 were obtained.
Cronbach's alpha coefficient of the Chinese self-report HAMD-6 was 0.91, and the intra-group correlation coefficient (ICC) of retest reliability was 0.81(P < 0.01). The Spearman correlation coefficients of the Chinese self-report HAMD-6, Chinese clinician version of HAMD-6, PHQ-9 and HAMD-17 were 0.86, 0.81 and 0.86, respectively (all P < 0.01). Results of the confirmatory factor analysis (CFA) supported a unidimensional construct. In addition, HAMD-17 ≤ 7 and iCGI-S= 1 were taken as the remission criteria for depression disorder, and the ROC curves of the Chinese self-report HAMD-6 were plotted with a cut-off value of 3/4, the specificity and sensitivity were 0.85/0.92 and 0.96/0.93 respectively.
These results suggested that the abbreviated Chinese self-report HAMD-6 has good reliability and validity among the Chinese population. This study suggested that the remission cut-off value of the scale is 3/4.
本研究旨在验证中文版汉密尔顿抑郁量表 6 项（HAMD-6）的心理测量学特征。
本研究采用中文版 HAMD-6、17 项汉密尔顿抑郁量表（HAMD-17）、患者健康问卷抑郁量表（PHQ-9）和临床医生总体印象量表（CGI-S）对符合 DSM-5 重性抑郁障碍（MDD）诊断标准的门诊和住院患者进行评估。考察了中文版 HAMD-6 的内部一致性信度、重测信度、效标效度和结构效度。采用 Pearson 相关系数评估总分与各条目得分的相关性。通过绘制受试者工作特征（ROC）曲线，得出中文版 HAMD-6 的最佳截断值、灵敏度和特异度。
中文版 HAMD-6 的克朗巴赫系数为 0.91，重测信度的组内相关系数（ICC）为 0.81（P<0.01）。中文版 HAMD-6 与中文版 HAMD-6 临床医师版、PHQ-9、HAMD-17 的Spearman 相关系数分别为 0.86、0.81 和 0.86（均 P<0.01）。验证性因子分析（CFA）结果支持单维结构。此外，以 HAMD-17≤7 和 CGI-S=1 作为抑郁障碍缓解的标准，绘制中文版 HAMD-6 的 ROC 曲线，以 3/4 为截断值，特异度和灵敏度分别为 0.85/0.92 和 0.96/0.93。
该研究结果表明，中文版 HAMD-6 具有良好的信度和效度，其缓解标准的截断值为 3/4。
