• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Age and sex differences in soluble ACE2 may give insights for COVID-19.

作者信息

Swärd Per, Edsfeldt Andreas, Reepalu Anton, Jehpsson Lars, Rosengren Björn E, Karlsson Magnus K

机构信息

Clinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.

Department of Cardiovascular Research-Translational Studies and Cardiology, Skåne University Hospital, Lund University, Malmö, Sweden.

出版信息

Crit Care. 2020 May 14;24(1):221. doi: 10.1186/s13054-020-02942-2.

DOI:10.1186/s13054-020-02942-2
PMID:32410690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7224163/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00a/7227287/b9b044f7a59e/13054_2020_2942_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00a/7227287/b9b044f7a59e/13054_2020_2942_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00a/7227287/b9b044f7a59e/13054_2020_2942_Fig1_HTML.jpg

相似文献

1
Age and sex differences in soluble ACE2 may give insights for COVID-19.可溶性血管紧张素转换酶2的年龄和性别差异可能为新冠病毒疾病提供见解。
Crit Care. 2020 May 14;24(1):221. doi: 10.1186/s13054-020-02942-2.
2
Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19.在一个大型队列中，可溶性血管紧张素转换酶2（ACE2）的血浆水平与性别、代谢综合征及其生物标志物相关，这表明了COVID-19病情加重的一种可能机制。
Crit Care. 2020 Jul 22;24(1):452. doi: 10.1186/s13054-020-03141-9.
3
Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection?ACE2 过表达是否是 COVID-19 感染的危险因素？
Arch Med Res. 2020 May;51(4):345-346. doi: 10.1016/j.arcmed.2020.03.011. Epub 2020 Apr 4.
4
COVID-19 infection: ACE2, pregnancy and preeclampsia.新型冠状病毒肺炎感染：血管紧张素转换酶2、妊娠与子痫前期
Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:330. doi: 10.1016/j.ejogrb.2020.08.007. Epub 2020 Aug 22.
5
Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?性激素使人类气道中的 ACE2 表达偏向一方：这是 COVID-19 中性别差异的一个促成因素吗？
Am J Physiol Lung Cell Mol Physiol. 2020 Nov 1;319(5):L843-L847. doi: 10.1152/ajplung.00391.2020. Epub 2020 Sep 30.
6
Genetic predisposition models to COVID-19 infection.新冠病毒感染的遗传易感性模型。
Med Hypotheses. 2020 Sep;142:109818. doi: 10.1016/j.mehy.2020.109818. Epub 2020 May 6.
7
ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?ACE2：理解 COVID-19 严重和危急情况病理生理学的关键分子：是魔鬼还是天使？
Viruses. 2020 Apr 28;12(5):491. doi: 10.3390/v12050491.
8
Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19.评估 COVID-19 发病机制中肺组织 ACE2 表达模式。
J Autoimmun. 2020 Aug;112:102463. doi: 10.1016/j.jaut.2020.102463. Epub 2020 Apr 13.
9
Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation.血管紧张素转换酶2（ACE2）和跨膜丝氨酸蛋白酶2（TMPRSS2）对新型冠状病毒肺炎（COVID-19）发病率和严重程度的性别介导效应；基因实施的必要性。
Curr Res Transl Med. 2020 Nov;68(4):149-150. doi: 10.1016/j.retram.2020.08.002. Epub 2020 Sep 6.
10
Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection.血管紧张素转换酶：表达谱及其与人类疾病的关联综述，特别关注 SARS-CoV-2 感染。
Vascul Pharmacol. 2020 Jul;130:106680. doi: 10.1016/j.vph.2020.106680. Epub 2020 May 11.

引用本文的文献

1
The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19.冠状病毒诱导的神经炎症中年龄依赖性神经胶质细胞与外周免疫细胞的相互作用，特别关注新型冠状病毒肺炎。
Biogerontology. 2025 May 17;26(3):111. doi: 10.1007/s10522-025-10252-9.
2
Elevated Soluble ACE2 Activity in Children and Adults After SARS-CoV-2 Exposure Irrespective of Laboratory-Confirmed Infection.SARS-CoV-2暴露后儿童和成人可溶性ACE2活性升高，与实验室确诊感染无关。
J Med Virol. 2024 Dec;96(12):e70098. doi: 10.1002/jmv.70098.
3
Predicting susceptibility to COVID-19 infection in patients on maintenance hemodialysis by cross-coupling soluble ACE2 concentration with lymphocyte count: an algorithmic approach.

本文引用的文献

1
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.意大利伦巴第地区 1591 名 ICU 收治的 SARS-CoV-2 感染患者的基线特征和结局。
JAMA. 2020 Apr 28;323(16):1574-1581. doi: 10.1001/jama.2020.5394.
2
The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science.2019冠状病毒病、衰老与心血管疾病的困境：心血管衰老科学的见解
JAMA Cardiol. 2020 Jul 1;5(7):747-748. doi: 10.1001/jamacardio.2020.1329.
3
Daily School Physical Activity from Before to After Puberty Improves Bone Mass and a Musculoskeletal Composite Risk Score for Fracture.
通过将可溶性血管紧张素转换酶2浓度与淋巴细胞计数交叉耦合来预测维持性血液透析患者对2019冠状病毒病感染的易感性：一种算法方法。
Front Med (Lausanne). 2024 Oct 30;11:1444719. doi: 10.3389/fmed.2024.1444719. eCollection 2024.
4
Clinical characteristics and risk factors of severe COVID-19 in hospitalized neonates with omicron variant infection: a retrospective study.奥密克戎变异株感染住院新生儿重症 COVID-19 的临床特征和危险因素：一项回顾性研究。
Ital J Pediatr. 2024 Sep 16;50(1):176. doi: 10.1186/s13052-024-01751-5.
5
ADAM-17 Activity and Its Relation to ACE2: Implications for Severe COVID-19.ADAM-17 的活性及其与 ACE2 的关系：对严重 COVID-19 的影响。
Int J Mol Sci. 2024 May 29;25(11):5911. doi: 10.3390/ijms25115911.
6
The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection.DNA 糖苷酶 NEIL2 在 SARS-CoV-2 感染过程中具有保护作用。
Nat Commun. 2023 Dec 9;14(1):8169. doi: 10.1038/s41467-023-43938-0.
7
Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era.后 COVID-19 时代心血管疾病的表型全基因组关联研究和精准医学。
Acta Pharmacol Sin. 2023 Dec;44(12):2347-2357. doi: 10.1038/s41401-023-01119-1. Epub 2023 Aug 2.
8
Diversity of immune responses in children highly exposed to SARS-CoV-2.儿童对 SARS-CoV-2 高度暴露后的免疫反应多样性。
Front Immunol. 2023 Mar 3;14:1105237. doi: 10.3389/fimmu.2023.1105237. eCollection 2023.
9
Editorial: COVID-19: From bedside to follow-up.社论：2019冠状病毒病：从床边到随访
Front Med (Lausanne). 2023 Feb 22;10:1155049. doi: 10.3389/fmed.2023.1155049. eCollection 2023.
10
Circulating angiotensin converting enzyme 2 and COVID-19.循环血管紧张素转换酶2与新型冠状病毒肺炎
World J Clin Cases. 2022 Dec 6;10(34):12470-12483. doi: 10.12998/wjcc.v10.i34.12470.
从青春期前到青春期后进行日常学校体育活动可改善骨量和骨折的肌肉骨骼综合风险评分。
Sports (Basel). 2020 Mar 28;8(4):40. doi: 10.3390/sports8040040.
4
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.血管紧张素转换酶2（ACE2）作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的受体：分子机制与潜在治疗靶点
Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.
5
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.血管紧张素 II 诱导心肌 ACE2 的蛋白水解切割是由 TACE/ADAM-17 介导的：RAS 中的正反馈机制。
J Mol Cell Cardiol. 2014 Jan;66:167-76. doi: 10.1016/j.yjmcc.2013.11.017. Epub 2013 Dec 9.
6
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.严重急性呼吸综合征冠状病毒（SARS-CoV）的刺突蛋白和血管紧张素转换酶2（ACE2）对肿瘤坏死因子-α转换酶的调节可诱导肿瘤坏死因子-α的产生并促进病毒进入。
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7809-14. doi: 10.1073/pnas.0711241105. Epub 2008 May 19.