Grimm Anna-Sophie, Schubert Charlotte, Grimm Alexander, Stahl Jan-Hendrik, Küpper Hanna, Horber Veronka, Kegele Josua, Willikens Sophia, Wittlinger Julia, Serna-Higuita Lina, Winter Natalie, Groeschel Samuel
Department of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, Germany.
Department of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.
Front Neurol. 2020 Apr 28;11:303. doi: 10.3389/fneur.2020.00303. eCollection 2020.
We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies. High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out. Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases. Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies.
我们旨在建立8至17岁儿童和青少年的神经超声参考数据，并将这些数据与年幼儿童、成年人以及患有多发性神经病的年龄匹配儿童进行比较。对117名健康儿童和青少年双侧颈部及四肢的20个预定义标志点进行了神经高分辨率超声检查。计算了平均值、左右差异和神经内比值以及上限。第二步，对25名年龄范围相同、已证实患有遗传性和获得性神经病以及溶酶体贮积病的儿童和青少年进行了比较。神经生长与年龄显著相关，在15岁左右达到成人水平。在大多数节段，体重指数和性别的影响可以忽略不计。通过使用特定年龄的上限，可以在不同类型的神经病中看到神经增粗，特别是在脱髓鞘遗传性和炎症性类型中，这与成年人的发现相当，在罕见的溶酶体贮积病中也有发现。儿童期神经大小与年龄相关，并在年轻成年人中达到峰值。年龄匹配的参考数据在肥厚性和非肥厚性神经损伤（如神经病）之间不可避免地存在差异。
