Grusauskiene Evelina, Smigelskyte Agne, Qerama Erisela, Rastenyte Daiva
Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Department of Clinical Neurophysiology, Aarhus University Hospital, 8200 Aarhus, Denmark.
Diagnostics (Basel). 2025 Jun 11;15(12):1484. doi: 10.3390/diagnostics15121484.
: We aimed to compare well-known ultrasound protocols for inflammatory polyneuropathies in a single cohort. : High-resolution ultrasound was performed according to the Bochum ultrasound score (BUS)/neuropathy ultrasound protocol (NUP), ultrasound pattern sum score (UPSS), and EAN/PNS suggested protocol for patients with chronic (CIDP) and acute inflammatory polyneuropathies (AIDP), multifocal motor neuropathies (MMN) and healthy controls. The upper boundaries were adjusted according to our laboratory normative values to all above-mentioned protocols; additionally, another calculation was performed using the peripheral nerve size values officially proposed by EAN/PNS. : We enrolled a total of 189 subjects (105 males and 84 females), comprising 40 patients with CIDP, 13 with MMN, 11 with AIDP, and 125 healthy controls. The mean ages were 62.49 years (range 37-84 years) for the CIDP patients; 55.92 years (range 32-71 years) for the MMN patients; 68.09 years (range 51-88 years) for the AIDP patients; and 49.02 years (range 25-80 years) for the healthy controls. Using the EAN/PNS protocol bilaterally, 72.9% of CIDP cases were identified. When the adjusted EAN/PNS protocol was applied, the detection rate rose to 100%, with a sensitivity of 100%. Both the adjusted BUS/NUP and UPSS protocols demonstrated a specificity of 90% in diagnosing CIDP. EAN/PNS protocol detected 69.23% of MMN cases measured unilaterally and had a 100% sensitivity to distinguish MMN, while the UPSS protocol had the highest specificity (96%). In AIDP cases, the adjusted EAN/PNS protocol identified 90.90% of cases through unilateral or bilateral measurements, with sensitivity 91% and specificity 88%. : The EAN/PNS protocol was the most valuable in the detection of treatable states, and the BUS/NUP, UPSS protocols were the most valuable in the differentiation of specific inflammatory polyneuropathies.
我们旨在对单一队列中用于炎性多发性神经病的知名超声检查方案进行比较。对慢性炎性脱髓鞘性多发性神经病（CIDP）、急性炎性脱髓鞘性多发性神经病（AIDP）、多灶性运动神经病（MMN）患者及健康对照，根据波鸿超声评分（BUS）/神经病超声检查方案（NUP）、超声模式总和评分（UPSS）以及欧洲神经病学学会（EAN）/周围神经病学会（PNS）建议的方案进行高分辨率超声检查。根据我们实验室的正常参考值对上述所有方案的上限进行了调整；此外，还使用EAN/PNS正式提出的周围神经大小值进行了另一项计算。我们共纳入了189名受试者（105名男性和84名女性），其中包括40例CIDP患者、13例MMN患者、11例AIDP患者和125名健康对照。CIDP患者的平均年龄为62.49岁（范围37 - 84岁）；MMN患者为55.92岁（范围32 - 71岁）；AIDP患者为68.09岁（范围51 - 88岁）；健康对照为49.02岁（范围25 - 80岁）。双侧使用EAN/PNS方案时，72.9%的CIDP病例可被识别。应用调整后的EAN/PNS方案时，检出率升至100%，敏感性为100%。调整后的BUS/NUP和UPSS方案在诊断CIDP时特异性均为90%。EAN/PNS方案单侧测量时可检测出69.23%的MMN病例，区分MMN的敏感性为100%，而UPSS方案的特异性最高（96%）。在AIDP病例中，调整后的EAN/PNS方案通过单侧或双侧测量可识别90.90%的病例，敏感性为91%，特异性为88%。EAN/PNS方案在可治疗状态的检测中最有价值，而BUS/NUP、UPSS方案在特定炎性多发性神经病的鉴别中最有价值。
