年轻成年女性中脂联素水平及基因变异与体重指数的关系。
The Relationship of adiponectin level and gene variants with BMI among young adult women.
作者信息
Khabour Omar F, Alomari Mahmoud A, Abu Obaid Asmaa A
机构信息
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan 22110.
Division of Physical Therapy, Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid, Jordan 22110.
出版信息
Dermatoendocrinol. 2018 Jun 18;10(1):e1477902. doi: 10.1080/19381980.2018.1477902. eCollection 2018.
The current study examined the effect of single nucleotide (SNPs) polymorphisms in the gene (I146T and G276T) on body mass index (BMI) of young adult women. The women were divided into underweight, normal, overweight and obese according to BMI. The circulating levels of adiponectin were measured using commercially available ELISA kits. Genetic polymorphisms were genotyped using the PCR-RFLP method. G276T and I164T SNPs are common in the examined population as the frequency of G allele of 276 SNP was 54.8% and for the T allele of 164 SNP it was 41.7%. Circulating adiponectin levels were related to BMI and were lowest in the obese versus overweight, normal weight and underweight groups (p<0.01). However, gene SNPs (I146T and G276T) showed no association with BMI groups. In conclusion, the results may suggest that adiponectin level, but not gene SNPs, is a good indicator to BMI in young adult women.
本研究检测了该基因（I146T和G276T）中的单核苷酸多态性（SNPs）对年轻成年女性体重指数（BMI）的影响。根据BMI将这些女性分为体重过轻、正常、超重和肥胖组。使用市售酶联免疫吸附测定（ELISA）试剂盒测量脂联素的循环水平。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对基因多态性进行基因分型。G276T和I164T SNPs在所检测人群中较为常见，276 SNP的G等位基因频率为54.8%，164 SNP的T等位基因频率为41.7%。脂联素的循环水平与BMI相关，在肥胖组中最低，与超重、正常体重和体重过轻组相比有差异（p<0.01）。然而，该基因的SNPs（I146T和G
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