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When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients?当大流行发生时,没有时间可以浪费:我们的应对新冠肺炎感染患者的手段中应该有羟氯喹吗?
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2
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Pharmaceutical care of chloroquine phosphate in elderly patients with coronavirus pneumonia (COVID-19).磷酸氯喹在老年新型冠状病毒肺炎(COVID-19)患者中的药学监护
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Hydroxychloroquine and QT Prolongation in Older Patients with Rheumatic Diseases: Who is afraid of the Boogeyman? We are not!老年风湿性疾病患者中羟氯喹与QT间期延长:谁害怕这可怕的东西?我们不怕!
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7
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Mediterr J Rheumatol. 2020 Mar 31;31(1):1-2. doi: 10.31138/mjr.31.1.1. eCollection 2020 Mar.

本文引用的文献

1
A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.一项关于氯喹治疗 COVID-19 的疗效和安全性的系统评价。
J Crit Care. 2020 Jun;57:279-283. doi: 10.1016/j.jcrc.2020.03.005. Epub 2020 Mar 10.
2
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?氯喹抗冠状病毒的抗病毒作用的新见解:对 COVID-19 有何期待?
Int J Antimicrob Agents. 2020 May;55(5):105938. doi: 10.1016/j.ijantimicag.2020.105938. Epub 2020 Mar 12.
3
[Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia].《磷酸氯喹治疗新型冠状病毒肺炎专家共识》
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):185-188. doi: 10.3760/cma.j.issn.1001-0939.2020.03.009.
4
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).羟氯喹治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)的体外抗病毒活性和优化剂量设计预测。
Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
5
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒(2019 - 新冠病毒)。
Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4.
6
Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.通过氯喹类似物靶向内体酸化作为治疗新出现病毒性疾病的一种有前景的策略。
Pharmacol Res Perspect. 2017 Jan 23;5(1):e00293. doi: 10.1002/prp2.293. eCollection 2017 Feb.
7
Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice.氯喹对新生小鼠人冠状病毒OC43感染的抗病毒活性
Antimicrob Agents Chemother. 2009 Aug;53(8):3416-21. doi: 10.1128/AAC.01509-08. Epub 2009 Jun 8.
8
Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.氯喹对人肺上皮细胞(L132)中人类冠状病毒229E感染的抑制作用:p38丝裂原活化蛋白激酶和细胞外信号调节激酶的参与
Antiviral Res. 2008 Feb;77(2):150-2. doi: 10.1016/j.antiviral.2007.10.011. Epub 2007 Nov 20.
9
New insights into the antiviral effects of chloroquine.氯喹抗病毒作用的新见解。
Lancet Infect Dis. 2006 Feb;6(2):67-9. doi: 10.1016/S1473-3099(06)70361-9.
10
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.氯喹是一种有效的严重急性呼吸综合征冠状病毒感染和传播抑制剂。
Virol J. 2005 Aug 22;2:69. doi: 10.1186/1743-422X-2-69.

当大流行发生时,没有时间可以浪费:我们的应对新冠肺炎感染患者的手段中应该有羟氯喹吗?

When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients?

作者信息

Bogdanos Dimitrios P, Daniil Zoi, Zakynthinos Epaminondas, Gourgoulianis Konstantinos, Sakkas Lazaros I

机构信息

Department of Rheumatology and Clinical Immunology.

Department of Respiratory Medicine, and.

出版信息

Mediterr J Rheumatol. 2020 Mar 31;31(1):94-97. doi: 10.31138/mjr.31.1.94. eCollection 2020 Mar.

DOI:10.31138/mjr.31.1.94
PMID:32411941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7219635/
Abstract

The current use of chloroquine and/or hydroxychloroquine, a drug currently used to treat autoimmune rheumatic diseases, in treating severe acute respiratory syndrome caused by coronavirus 2 (SARSCoV-2) or COVID-19-infected patients with pneumonia is a matter of intense consideration. We wish to enter the ongoing debate as to whether this well-known drug must be given to Greek COVID-19-infected patients, especially those with pneumonia. Our arguments are based on the existing data and the capacity of the Greek health system to afford potent anti-viral treatments, which are under immense investigation. We propose several suggestions related to treatment of COVID-19 pneumonia with chloroquine/hydroxychloroquine that we think must be taken into consideration to fit the evolving situation of the pandemic in Greece.

摘要

目前用于治疗自身免疫性风湿疾病的氯喹和/或羟氯喹,在治疗由冠状病毒2(SARS-CoV-2)引起的严重急性呼吸综合征或感染新冠肺炎且患有肺炎的患者方面,正受到激烈讨论。我们希望参与到这场正在进行的辩论中,即这种知名药物是否必须用于希腊感染新冠肺炎的患者,尤其是那些患有肺炎的患者。我们的观点基于现有数据以及希腊医疗系统提供强效抗病毒治疗的能力,而这些治疗正在深入研究中。我们针对使用氯喹/羟氯喹治疗新冠肺炎肺炎提出了若干建议,我们认为必须考虑这些建议以适应希腊疫情的不断变化的形势。