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Hydroxychloroquine and QT Prolongation in Older Patients with Rheumatic Diseases: Who is afraid of the Boogeyman? We are not!

作者信息

Castagna Alberto, Ruotolo Giovanni, Manzo Ciro

机构信息

Azienda Sanitaria Provinciale Catanzaro, Geriatric Medicine department - Fragility Outpatient Clinic, Casa della Salute Chiaravalle Centrale, Catanzaro, Italy.

Azienda Ospedaliera Pugliese-Ciaccio di Catanzaro, Geriatric Unit, General Hospital, Catanzaro, Italy.

出版信息

Mediterr J Rheumatol. 2020 Dec 22;31(4):433-435. doi: 10.31138/mjr.31.4.433. eCollection 2020 Dec.

DOI:10.31138/mjr.31.4.433
PMID:33521580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7841093/
Abstract
摘要

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Hydroxychloroquine and QT Prolongation in Older Patients with Rheumatic Diseases: Who is afraid of the Boogeyman? We are not!老年风湿性疾病患者中羟氯喹与QT间期延长：谁害怕这可怕的东西？我们不怕！
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本文引用的文献

1
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).COVID-19 住院患者使用羟氯喹（无论是否联合使用阿奇霉素）导致 QT 间期延长的风险。
JAMA Cardiol. 2020 Sep 1;5(9):1036-1041. doi: 10.1001/jamacardio.2020.1834.
2
The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin.接受羟氯喹和阿奇霉素治疗的新冠肺炎患者的QT间期。
Nat Med. 2020 Jun;26(6):808-809. doi: 10.1038/s41591-020-0888-2.
3
When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients?当大流行发生时，没有时间可以浪费：我们的应对新冠肺炎感染患者的手段中应该有羟氯喹吗？
Mediterr J Rheumatol. 2020 Mar 31;31(1):94-97. doi: 10.31138/mjr.31.1.94. eCollection 2020 Mar.
4
Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature.氯喹和羟氯喹相关的心脏并发症：文献系统综述。
Drug Saf. 2018 Oct;41(10):919-931. doi: 10.1007/s40264-018-0689-4.
5
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.羟氯喹通过调节超极化激活电流If降低心率：新的电生理见解和治疗潜力。
Heart Rhythm. 2015 Oct;12(10):2186-94. doi: 10.1016/j.hrthm.2015.05.027. Epub 2015 May 27.
6
Association between the physical activity and heart rate corrected-QT interval in older adults.
Geriatr Gerontol Int. 2015 Jul;15(7):895-901. doi: 10.1111/ggi.12365. Epub 2014 Sep 20.
7
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.预测住院患者QT间期延长风险评分的开发与验证
Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):479-87. doi: 10.1161/CIRCOUTCOMES.113.000152. Epub 2013 May 28.
8
Polymorphic ventricular tachycardia, long Q-T syndrome, and torsades de pointes.多形性室性心动过速、长QT综合征和尖端扭转型室性心动过速。
Med Clin North Am. 2001 Mar;85(2):321-41. doi: 10.1016/s0025-7125(05)70318-7.