Rim Kyung-Taek
Chemicals Research Bureau, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Daejeon, Korea.
Toxicol Environ Health Sci. 2020;12(2):99-108. doi: 10.1007/s13530-020-00053-7. Epub 2020 Mar 19.
Various papers related to the application of adverse outcome pathways (AOPs) for the prevention of occupational disease were reviewed. The Internet was used as the primary tool to search for the necessary research data and information, using such online resources as Google Scholar, ScienceDirect, Scopus, NDSL, and PubMed. The key search terms were "adverse outcome pathway," "toxicology," "risk assessment," "human," "worker," "occupational safety and health," and so on.
The aim of this paper is to explain the use of AOP for the understanding of chemical toxicity as a conceptual means and to predict the toxic mechanism. The tools of AOP have emerged as a forward-looking alternative to the existing chemical risk assessment paradigm. AOP is being applied to the assessment of acute toxicity and to chronic toxic chemicals in the workplace. Not only can it lead to breakthroughs in occupational and environmental cancer prevention, it is also widely used in chemical risk assessment and has led to breakthroughs in the prevention of occupational disease in the workplace.
对多篇关于应用不良结局途径（AOPs）预防职业病的论文进行了综述。以互联网作为主要工具，利用谷歌学术、ScienceDirect、Scopus、NDSL和PubMed等在线资源搜索所需的研究数据和信息。关键检索词为“不良结局途径”“毒理学”“风险评估”“人类”“工人”“职业安全与健康”等。
本文旨在阐释将AOP用作理解化学毒性的概念手段并预测毒性机制。AOP工具已成为现有化学风险评估范式的前瞻性替代方法。AOP正应用于急性毒性评估以及工作场所慢性有毒化学品的评估。它不仅能在职业和环境癌症预防方面带来突破，还广泛应用于化学风险评估，并在工作场所职业病预防方面取得了突破。
