Kang Doo Seok, Kim Hyun Soo, Jung Jong-Hyeon, Lee Cheol Min, Ahn Yeon-Soon, Seo Young Rok
Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea.
Faculty of Health Science, Daegu Haany University, Gyeongsan, Gyeongbuk, 38610, Republic of Korea.
Genes Environ. 2021 Apr 12;43(1):13. doi: 10.1186/s41021-021-00183-5.
Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemia studies. However, the correlation between formaldehyde exposure and leukemia incidence is a controversial issue. To understand the association between formaldehyde exposure and leukemia, we explored biological networks based on formaldehyde-related genes retrieved from public and commercial databases. Through the literature-based network approach, we summarized qualitative associations between formaldehyde exposure and leukemia. Our results indicate that oxidative stress-mediated genetic changes induced by formaldehyde could disturb the hematopoietic system, possibly leading to leukemia. Furthermore, we suggested major genes that are thought to be affected by formaldehyde exposure and associated with leukemia development. Our suggestions can be used to complement experimental data for understanding and identifying the leukemogenic mechanism of formaldehyde.
甲醛是一种广泛使用但具有高反应性和毒性的化学物质。基于鼻咽癌和白血病研究，国际癌症研究机构将甲醛归类为1类致癌物。然而，甲醛暴露与白血病发病率之间的相关性是一个有争议的问题。为了了解甲醛暴露与白血病之间的关联，我们基于从公共和商业数据库中检索到的与甲醛相关的基因，探索了生物网络。通过基于文献的网络方法，我们总结了甲醛暴露与白血病之间的定性关联。我们的结果表明，甲醛诱导的氧化应激介导的基因变化可能会扰乱造血系统，可能导致白血病。此外，我们提出了一些被认为受甲醛暴露影响并与白血病发展相关的主要基因。我们的建议可用于补充实验数据，以理解和确定甲醛的致白血病机制。
