Poulter N R, Shipley M J, Bulpitt C J, Markowe H J, Marmot M G
University College and Middlesex School of Medicine, London, UK.
J Hypertens Suppl. 1988 Dec;6(4):S611-3. doi: 10.1097/00004872-198812040-00191.
Blood pressures, pulse rates and 24-h urinary electrolyte content were measured in 371 male and 125 female randomly selected civil servants. The male and female subjects were divided into nine subgroups each, by tertiles of sodium (Na) excretion and tertiles of pulse rate. Those in the subgroup with highest values for both variables had the highest mean systolic and diastolic blood pressure (adjusted to age 50 years and a body mass index of 25 kg/m2) among the male and female groups, and those in the subgroup with lowest values for both variables had the lowest systolic pressure among the male and female groups and the lowest diastolic pressure of the female groups. Both systolic and diastolic blood pressure were significantly related to an interaction term between urinary Na excretion and pulse rate among males (P less than 0.02, P less than 0.03 respectively). These data support the hypothesis that psychological stress (assessed by pulse) and dietary sodium (assessed by sodium excretion) may interact to determine levels of blood pressure.
对371名男性和125名女性随机选取的公务员测量了血压、脉搏率和24小时尿电解质含量。根据钠（Na）排泄三分位数和脉搏率三分位数，将男性和女性受试者各分为9个亚组。在男性和女性组中，两个变量值最高的亚组的平均收缩压和舒张压最高（校正至50岁年龄和体重指数25kg/m2），而两个变量值最低的亚组的收缩压在男性和女性组中最低，舒张压在女性组中最低。男性的收缩压和舒张压均与尿钠排泄和脉搏率之间的交互项显著相关（分别P<0.02，P<0.03）。这些数据支持以下假设：心理压力（通过脉搏评估）和膳食钠（通过钠排泄评估）可能相互作用以决定血压水平。
